Trio-based whole-exome sequencing reveals mutations in early-onset high myopia.

Purpose: Myopia, especially high myopia (HM), represents a widespread visual impairment with a globally escalating prevalence. This study aimed to elucidate the genetic foundations associated with early-onset HM (eoHM) while delineating the genetic landscape specific to Shaanxi province, China.

Methods: A comprehensive analysis of whole-exome sequencing was conducted involving 26 familial trios displaying eoHM.

Comparative efficacy and safety of different anti-VEGF agents combined with different delivery methods for neovascular glaucoma: a systematic review and Bayesian network meta-analysis.

Objective: To compare the efficacy and safety of different anti-vascular endothelial growth factor (VEGF) agents combined with different delivery methods for neovascular glaucoma (NVG).

Design: Systematic review and Bayesian network meta-analysis (NMA).

Data Sources: PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials.

Plasma-derived from human umbilical cord blood restores ovarian function and improves serum reproductive hormones levels in mice with premature ovarian insufficiency (POI) through cytokines and growth factors.

Premature ovarian insufficiency (POI) patients experience a decline in ovarian function and a reduction in serum reproductive hormones, leading to a significant impact on the outcomes of assisted reproductive technology. Despite the absence of an effective clinical treatment to restore fertility in POI patients, recent research has indicated that cord blood plasma (CBP) derived from human umbilical cord blood (hUCB) may offer therapeutic benefits for various degenerative diseases. The primary aim of this study is to explore approaches for enhancing ovarian function and serum reproductive hormones through the administration of CBP in a murine model.

Advances in the study of Müller glia reprogramming in mammals.

Müller cells play an integral role in the development, maintenance, and photopic signal transmission of the retina. While lower vertebrate Müller cells can differentiate into various types of retinal neurons to support retinal repair following damage, there is limited neurogenic potential of mammalian Müller cells. Therefore, it is of great interest to harness the neurogenic potential of mammalian Müller cells to achieve self-repair of the retina.

Effectiveness of toric soft contact lenses for vision correction in patients with different degrees of astigmatism: a real-world study.

Aim: To assess the visual correction of patients with different degrees of astigmatism with toric soft contact lenses (TSC).

Methods: It was a real-world study with prospective and single-arm design. A total of 384 patients with astigmatism who came for TSC fitting and alignment from November 2022 to January 2023 were included.

The dead lithium formation under mechano-electrochemical coupling in lithium metal batteries.

Lithium metal is one of the most promising anode materials for next-generation high-energy-density rechargeable batteries. A fundamental mechanism understanding of the dead lithium formation under the interplay of electrochemistry and mechanics in lithium metal batteries is strongly considered. Herein, we proposed a mechano-electrochemical phase-field model to describe the lithium stripping process and quantify the dead lithium formation under stress.

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved.

Objective: Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level.

CLEC3B is a novel causative gene for macular-retinal dystrophy.

Purpose: Macular degeneration is the leading cause of blindness worldwide. In this study, we aimed to define a new subtype of macular-retinal dystrophy and its genetic predisposition in 5 families.

Methods: Exome sequencing was performed to determine the putative disease-causing genes in patients with inherited macular disorders confirmed through comprehensive ophthalmic examinations.

Serum Periostin Level and Genetic Polymorphisms Are Associated with Vertebral Fracture in Chinese Postmenopausal Women.

Purposes: In order to investigate the association between serum periostin levels and the variation of its encoding gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women, an association study was performed.

Materials And Methods: 385 postmenopausal women were recruited. For participants without a history of vertebral fracture, lateral X-rays of the spine covering the fourth thoracic spine to the fifth lumbar spine were performed to detect any asymptomatic vertebral fractures.

Research progress of melatonin (MT) in improving ovarian function: a review of the current status.

Melatonin (MT) is an endogenous hormone mainly synthesized by pineal cells, which has strong endogenous effects of eliminating free radicals and resisting oxidative damages. Melatonin (MT) can not only regulate the body's seasonal and circadian rhythms; but also delay ovarian senescence, regulate ovarian biological rhythm, promote follicles formation, and improve oocyte quality and fertilization rate. This review aimd to provide evidence concerning the synthesis and distribution, ovarian function, and role of MT in development of follicles and oocytes.

Drought-Tolerant Shows Rapid Expression of Gene Networks for General Stress Responses and Programmed Cell Death Under Simulated Drought Stress.

Production of oilseed rape/canola () is increasingly threatened by dry conditions while the demand for vegetable oil is increasing. is a genetically diverse ancestor of , and is readily crossed with . Recently, we reported promising levels of drought tolerance in a wild type of which could be a source of drought tolerance for .

Effects of background electrolytes and ionic strength on enrichment of Cd(II) ions with magnetic graphene oxide-supported sulfanilic acid.

To elucidate the influence mechanisms of background electrolytes and ionic strength on Cd(II) removal, the adsorption of Cd(II) onto magnetic graphene oxide-supported sulfanilic acid (MGO-SA) in aqueous solutions containing different types and concentrations of background electrolytes was studied. The results indicate that Cd(II) adsorption was strongly dependent on pH and could be strongly affected by background electrolytes and ionic strength. The Cd(II) removal was decreased with the presence of background electrolyte cations (Na(+), K(+), Ca(2+), Mg(2+), Mn(2+), Zn(2+), and Ni(2+)), and the divalent cations exerted more obvious influences on the Cd(II) uptake than the monovalent cations at pH 6.

Delayed water loss and temperature rise in floral buds compared with leaves of Brassica rapa subjected to a transient water stress during reproductive development.

Leaf canopy temperature has been proposed as a rapid selection tool for drought tolerance among crop genotypes. However, floral bud temperature may be a better indicator of drought tolerance than leaf temperature in grain crops. In this study, we examined whether the floral bud and leaves of Brassica rapa L.

[Analysis on processing mechanism of calamine].

Objective: To study processing method and mechanism of Calamine.

Method: Thermogravimetry analysis method and nano-technology were adopted to analyze and synthesize the components in Calamine, Tetracycline was took as the comparison drug to determine the antibacterial activity of Calamine and its components.

Result: A part of zinc carbonate in Calamine was decomposed into zinc oxide when processing, and the particle size was smaller than before.