Xanthones from antagonized the antirheumatic effects of methotrexate by promoting its secretion into urine.

Background: This study was designed to characterize the interaction between Hassk. derived xanthones and methotrexate (MTX).

Methods: Collagen-induced arthritis (CIA) was induced in rats, which were treated with MTX, a xanthone-rich fraction (XRF), or MTX+XRF by gavage for 30 days.

Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study.

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance liquid chromatography (HPLC) electrospray tandem mass spectrometer system.

[Classification and surgical treatment of the deviated nose with unilateral cleft lip].

Objective: To present a classification of the deviated nose with unilateral cleft lip and the associated surgical correction.

Methods: A total of 176 cases of nasal deformities with unilateral cleft lip treated in Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine & Shanghai Research Institute of Stomatology & Shanghai Key Laboratory of Stomatology from 2007 to 2009 were analyzed. Depending on the relationship between the external pyramid and the facial midline, the nasal deviations with cleft lip were classified into 3 types: I, deviated bony pyramid, II, deviated cartilaginous pyramid; III, deviated lobular.

[Treatment of cleft lip and palate: past, present and future].

Comparing the survey results of 224 Centers of Cleft Lip and Palate in the United States with the current status in China, and reviewing the experience and lessons systemically, we could get a conclusion that the repair of cleft lip and palate depends on the experience and excellent skills of the surgeons, and its important role in combined and sequential treatment (team approach) of cleft lip and palate should not be ignored. The team approach program requires multidisciplinary cooperation and good compliance of the patients. In order to improve the treatment outcomes of cleft lip and palate, it is necessary for us to study the advanced program and methods and combined the situation of our country.

[Primary study of pharyngeal flap surgery in congenital velopharyngeal insufficiency].

Objective: To study effective operation method of congenital velopharyngeal insufficiency by reviewing clinical data of 29 patients with pharyngoplasties.

Methods: 29 patients (9 male and 20 female, ranged from 4 to 25 years old, mean age was 13.5) with congenital velopharyngeal insufficiency were available for this study.

[A preliminary study of the influence of different consonants on the vowel in normal people].

Purpose: To study the influence of different consonants on the vowel in normal people for guiding research and treatment of cleft palate misarticulations.

Methods: 35 normal students including 15 males and 20 females were selected for this study. The average age was 20.

[Surgery for velopharyngeal insufficiency: a review of 219 modified pharyngoplasties].

Objective: Two-hundreds and nineteen velopharyngeal insufficiency cases treated with a modified pharyngoplasty were retrospectively analyzed, the effectiveness of the surgery was studied.

Methods: Two-hundreds and nineteen patients (111 males, 108 females, range from 4 to 33 years, mean age 14.2 years) with velopharyngeal insufficiency were studied.

[Intelligence evaluation of 22 patients with congenital velopharyngeal incompetence].

Objective: To study the intelligence of 22 patients with CVPI.

Methods: We examined the IQ of 22 patients with CVPI by Wechsler Primary Preschool Scale of Intelligence (WPSSI) and Wechsler Intelligence Scale for Children-Revised (WISC-R).

Results: The IQ of patients with CVPI was 44-109.

[Clinical practice of behavior therapy in speech treatment].

Objective: To apply behavior therapy to treat patients with velopharyngeal insufficiency(VPI),with the aim of improving speech treatment.

Methods: 20 patients(10 male, 10 female,ranged from 4.0 to 38.

[The study on the acoustic features of congenital velopharyngeal insufficiency in 28 patients].

Objective: To study the acoustic features of the patients with congenital velopharyngeal insufficiency (CVPI).

Methods: The acoustic features of 28 patients with CVPI were analyzed with the computer speech lab, contrasted by the features of 20 controls.

Results: There was significant difference in F2, B2, F3, B3 and VOT between the patients and the controls (P<0.

[A preliminary study on speech therapy for adult cleft palate patients].

Objective: To study speech feature and treatment of adult with misarticulation by review 20 patients' clinical information.

Methods: 20 adult patients (10 male, 10 female, age ranging from 20 to 38 years, mean age 20.35 years) with misarticulation were available for this study.

[The evaluation of the Chinese intelligibility of patients with velopharyngeal incompetence].

Objective: To study the Chinese intelligibility of patients with velopharyngeal incompetence (VPI).

Methods: 100 patients with VPI and 32 normal students were selected for this study. Of 10 patients, 15 with cleft palate, 21 with congenital velopharyngeal incompetence, 56 with post-palatoplasty VPI and 8 with post-pharyngoplasty VPI.