Publications by authors named "Yi-fan Zhu"
Chromatin Regulation of Acetic Acid Stress Tolerance by Ino80 in Budding Yeast .
J Agric Food Chem
January 2025
Enhanced environmental stress tolerance is important for microbial production of biofuels and biobased chemicals. However, the roles of chromatin regulation in stress tolerance and bioproduction remain unclear. Here, we explore the effects of Ino80, the core subunit of the INO80 chromatin remodeling complex, on yeast stress adaptation.
View Article and Find Full Text PDFℤ-classified higher-order topological insulators (HOTIs) with chiral-symmetric higher-order topological phases protected by multipole chiral numbers (MCNs) have attracted extensive interest recently. However, how to design artificial ℤ-classified HOTIs with multiple topological phases remains an unresolved issue. Here, multiorbital degrees of freedom are introduced to acoustic crystals and the various methods of topological phase transitions are achieved for the orbital ℤ-classified HOTIs.
View Article and Find Full Text PDFMembrane transport engineering for efficient yeast biomanufacturing.
Bioresour Technol
December 2024
Yeast strains have been widely recognized as useful cell factories for biomanufacturing. To improve production efficiency, their biosynthetic pathways and regulatory strategies have been continuously optimized. However, commercial production using yeasts is still limited by low product yield and high production cost.
View Article and Find Full Text PDFObjective: To construct and validate a new thyroid imaging reporting and data system (TI-RADS) based on radiating blood flow and grayscale US features.
Materials And Methods: This study enrolled patients from 4 hospitals from January 2018 to November 2023 retrospectively and prospectively. All US features associated with malignant thyroid nodules were assessed by multivariable logistic regression to construct baseline US TI-RADS (BUS TI-RADS), which was tested with internal validation set, external validation set and prospective validation set.
Article Synopsis
- - This study presents the first comprehensive genome assembly of a significant plant in traditional Chinese medicine, revealing its edible and medicinal traits while addressing the lack of genomic resources.
- - The genome assembly is high-quality at 679.20 Mb, anchored to 8 pseudo-chromosomes with a 96.5% anchoring rate and demonstrates high completeness at 97.6%, indicating a well-structured genomic framework.
- - The research highlights the evolutionary history of the plant, including its polyploidization and gene family expansions, providing critical insights for conservation and sustainable utilization of the species.
Article Synopsis
- * In a study with male rats, colchicine treatment significantly decreased myocardial damage after cardiopulmonary bypass and ischemia/reperfusion injury, while also elevating NET levels in heart tissue.
- * The findings suggest that colchicine protects the heart during surgery by targeting NET formation, with one mechanism being the inhibition of an enzyme called peptidylarginine deiminase 4.
Lamiales, comprising over 23,755 species across 24 families, stands as a highly diverse and prolific plant group, playing a significant role in the cultivation of horticultural, ornamental, and medicinal plant varieties. Whole-genome duplication (WGD) and its subsequent post-polyploid diploidization (PPD) process represent the most drastic type of karyotype evolution, injecting significant potential for promoting the diversity of this lineage. However, polyploidization histories, as well as genome and subgenome fractionation following WGD events in Lamiales species, are still not well investigated.
View Article and Find Full Text PDFObjective: To explore the performance of ultrasound image-based radiomics in predicting World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading of clear-cell renal cell carcinoma (ccRCC).
Methods: A retrospective study was conducted via histopathological examination on participants with ccRCC from January 2021 to August 2023. Participants were randomly allocated to a training set and a validation set in a 3:1 ratio.
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer's disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) have been implicated in olfactory impairment during the initial stages of AD. While the neuregulin 1 (NRG1)/ErbB4 signaling pathway is known to regulate GABAergic transmission in the brain and is associated with various neuropsychiatric disorders, its specific role in early AD-related olfactory impairment remains incompletely understood.
View Article and Find Full Text PDFObjective: To summary radiating blood flow signals and evaluate their diagnostic value in differentiating benign and malignant thyroid nodules.
Materials And Methods: We retrospectively recruited consecutive patients undergoing US at 4 hospitals from 2018 to 2022. In a training dataset, the correlations of US features with malignant thyroid nodules were assessed by multivariate logistic analysis.
Article Synopsis
- This study investigates the role of mutations in breast cancer patients in China, particularly focusing on hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative cases.
- Out of 629 women diagnosed with breast cancer, 78 (12.4%) had mutations, which were linked to lower average age at diagnosis and higher rates of lymph node positivity compared to non-mutation cases.
- Findings indicate that while mutation breast cancers had some adverse characteristics, such as a higher prevalence of familial breast and ovarian cancer history, mutations did not significantly impact invasive disease-free survival or distant relapse-free survival.
Article Synopsis
- The article with DOI: 10.3389/fimmu.2023.1153573 has been corrected for accuracy.
- The correction addresses specific errors or clarifications needed in the original publication.
- This ensures that readers have the most reliable and up-to-date information from the article.
Article Synopsis
- The study aimed to create and validate a predictive model for cytokeratin 7 (CK7) expression in clear cell renal cell carcinoma (ccRCC) using various ultrasound diagnostic methods.
- It involved 157 patients and used both univariate and multivariate logistic regression analyses to identify key factors influencing CK7 positivity, concluding that age, wash-in pattern, and enhancement homogeneity were significant indicators.
- The predictive model demonstrated strong accuracy with ROC curve areas of 0.812 for the training group and 0.792 for the testing group, indicating its clinical utility in predicting CK7 expression in ccRCC patients.
Article Synopsis
- The study investigates how contrast-enhanced ultrasound (CEUS) can be used to diagnose and grade bladder urothelial carcinoma (BUC) by analyzing data from 173 patients with bladder lesions.
- Results showed clear differences in blood flow and CEUS enhancement between BUC and benign lesions, with specific metrics (like the H/T ratio) effectively distinguishing between high and low grades of BUC.
- The findings suggest that using CEUS along with time-intensity curve analysis significantly enhances the diagnostic precision for identifying BUC and its severity.
Article Synopsis
- - BRCA2 mutation carriers face a significant lifetime risk for breast cancer, often developing it at a younger age and having heightened susceptibility to several other cancers.
- - A large majority (70-80%) of breast cancers in BRCA2 mutation carriers are classified as estrogen receptor (ER)-positive, which differs from the typical ER-positive breast cancer seen in the general population.
- - The article examines the clinical features, treatment options, and prognosis of ER-positive breast cancer in BRCA2 mutation carriers to aid in making informed clinical decisions.
Case Report: The application of metagenomic next generation sequencing in diagnosing fungal malignant external otitis: a report of two cases.
Front Cell Infect Microbiol
December 2023
Article Synopsis
- - Most cases of malignant external otitis (MEO) are linked to bacterial infections, while fungal infections are possible but very rare and hard to diagnose using standard microbiological methods.
- - In this case, two patients were successfully diagnosed with fungal malignant external otitis (FMEO) using metagenomic Next-Generation Sequencing (mNGS) and treated with surgery and voriconazole, although their antifungal treatment was initially delayed due to negative culture results.
- - The study suggests that mNGS can be a valuable tool for diagnosing FMEO in patients, particularly when traditional microbiological tests fail to identify the cause of the infection.
A comprehensive analysis of Fanconi anemia genes in Chinese patients with high-risk hereditary breast cancer.
J Cancer Res Clin Oncol
November 2023
Article Synopsis
- - The study examined the role of 16 Fanconi anemia (FA) genes in breast cancer (BC) among 1481 high-risk hereditary BC patients in China, identifying 38 patients with mutations in these genes, mainly FANCA.
- - Findings indicated that FA gene mutation carriers had worse clinicopathological features, including higher tumor sizes and lower survival rates compared to non-carriers, along with significant differences in lymph node status.
- - The research suggests that specific FA gene mutations may contribute to breast cancer risk, and further exploration is warranted to better understand their implications in various populations.
Article Synopsis
- Inflammation plays a key role in the development of pulmonary arterial hypertension (PAH), with immune cell activity being regulated by chemokines and their receptors; this study focuses on identifying crucial chemokines involved in PAH progression through transcriptomic analysis.
- Researchers analyzed gene expression data from PAH patients compared to controls, using methods like gene set enrichment analysis (GSEA) and weighted correlation network analysis (WGCNA) to discover diagnostic markers and understand immune cell involvement.
- The study found that ACKR4, an atypical chemokine receptor, was downregulated in PAH lung tissues, correlating with reduced immune cell activation; this suggests that ACKR4 may play a protective
Article Synopsis
- Alzheimer's disease (AD) is difficult to diagnose early, but retinal damage may indicate its onset before cognitive decline occurs.
- Salvianolic acid B (Sal B), derived from a traditional Chinese herb, shows potential in treating early-stage AD and retinopathy.
- In a study with 5×FAD mice, Sal B treatment improved retinal function and structure, suggesting it could help address early symptoms of AD by reducing harmful protein buildup and inflammation.
Article Synopsis
- High UV-B radiation poses challenges to Pinot noir grape growth in the Southern Hemisphere, but it doesn't affect fruit production, °Brix, or total amino acids over two years.
- The study found that UV-B exposure increased skin anthocyanin and total phenolic content in grapes, while some monoterpene concentrations decreased.
- Effective leaf canopy management is crucial, as it can enhance the accumulation of beneficial phenolic compounds, potentially improving the quality of Pinot noir.
Article Synopsis
- Olfactory dysfunction is one of the first signs of Parkinson's disease, linked to α-synuclein accumulation in the olfactory bulb.
- Research on SNCA-A53T mice revealed that while their motor skills remained unaffected, their ability to detect and differentiate odors was impaired due to abnormal signaling in the olfactory bulb.
- The study found that targeting GABA signaling with tiagabine improved olfactory function, suggesting a new approach for diagnosing and treating early-stage Parkinson's disease.
Article Synopsis
- The article being referenced is identified by its DOI number, indicating it covers a specific topic in immunology.
- The mention of "correction" suggests that there were updates or revisions made to the original article.
- The DOI provides a permanent link to access the corrected content for further review or citation.
Article Synopsis
- Sivelestat, a neutrophil elastase inhibitor, is being evaluated for its potential benefits in preventing acute lung injury (ALI) in patients who have undergone emergent cardiovascular surgery, contrasting previous studies focusing on scheduled cardiac surgeries.
- A study analyzed 665 patients, comparing 52 individuals who received sivelestat with 613 controls, and further narrowed the comparison using a propensity score matching method.
- Results indicated that while sivelestat did not significantly affect overall adverse outcomes like 30-day mortality, it notably reduced the incidence of pneumonia and mechanical ventilation time, suggesting it may provide important pulmonary protection post-surgery.
Article Synopsis
- The study assessed the effectiveness of combining real-time contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) for identifying three types of kidney cancer: clear cell renal cell carcinoma (CCRCC), papillary renal cell carcinoma (PRCC), and chromophobe renal cell carcinoma (CRCC).
- Out of 125 patients evaluated, the diagnostic accuracy was highest for CCRCC (87.8%), followed by PRCC (83.3%) and CRCC (73.7%), with no significant accuracy difference between CEUS and CECT (P>0.05).
- The study found distinct enhancement patterns using CEUS across the different cancer types, suggesting CEUS
Article Synopsis
- Cardiac hypertrophy, often caused by stressors like angiotensin II (Ang II), can lead to heart failure; this study investigates how miR-133a-3p affects pyroptosis in this context.
- Using various assays, the researchers found that Ang II induces hypertrophy and pyroptosis in heart cells, while miR-133a-3p expression decreases, offering protective effects when overexpressed.
- MiR-133a-3p targets IKKε, inhibiting its expression and thereby reducing pyroptosis and hypertrophy, suggesting that increasing miR-133a-3p could be a potential treatment for cardiac hypertrophy.