Publications by authors named "Yi-chu Chen"
Background: The World Health Organization aims for the global elimination of cervical cancer, necessitating modeling studies to forecast long-term outcomes.
Objective: This paper introduces a macrosimulation framework using age-period-cohort modeling and population attributable fractions to predict the timeline for eliminating cervical cancer in Taiwan.
Methods: Data for cervical cancer cases from 1997 to 2016 were obtained from the Taiwan Cancer Registry.
Article Synopsis
- Intra-arrest transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are new diagnostic tools used during cardiac arrest, but it's unclear which is more effective based on current research.
- A systematic review analyzed 27 studies involving adult patients, revealing that TTE detected positive findings in about half of patients, whereas TEE identified a higher percentage of CA causes, especially aortic dissection.
- Despite TEE's superior diagnostic ability, sonographic cardiac activity was reported more frequently with TTE, and the overall impact on patient survival and spontaneous circulation remains uncertain.
Article Synopsis
- The study evaluated the global prevalence of Helicobacter pylori (H pylori) infection in adults and children/adolescents, linking it to gastric cancer rates.
- After reviewing nearly 17,000 articles, researchers found that H pylori infection prevalence dropped from 52.6% to 43.9% in adults but remained at 35.1% in children and adolescents from 2015 to 2022.
- The decline in H pylori in adults was significant in certain regions, while the relationship between H pylori prevalence and decreasing gastric cancer incidence prompts the need for further large-scale clinical trials to confirm these findings.
Article Synopsis
- * A study analyzing data from the Taiwan Cancer Registry from 1997-2016 revealed that urban women had higher breast cancer rates than rural women, though rural rates increased more rapidly over time.
- * The research indicates that women born in 1992 faced significantly higher breast cancer risks compared to earlier cohorts, suggesting that urbanization and westernization may be contributing factors to changing incidence rates in Taiwan.
Article Synopsis
- Breast cancer is the most common cancer among women in Taiwan, with its incidence rate having doubled over the past 20 years, raising concerns among health professionals and the public.
- A study used advanced models to analyze breast cancer incidence trends from 1997 to 2016 and predict future trends, finding a rapid increase in age-standardized incidence rates, projected to reach a plateau by 2031.
- The majority of future breast cancer cases are expected to occur in women aged 55 and older, highlighting the need for education on lifestyle changes and regular mammography screening to mitigate the impact of the disease.
Article Synopsis
- * A study from 1997 to 2011 analyzed invasive breast cancer cases, revealing a significant cohort effect in South Korea, Taiwan, Japan, and Thailand, likely linked to westernization.
- * While an increase in breast cancer rates was observed in women born in Hong Kong and India, no birth cohort effect was seen in the Philippines or among ethnic groups in the U.S., highlighting differences in cultural influence on cancer trends.
Magnetic resonance elastography (MRE) has been used to successfully characterize the mechanical behavior of healthy and diseased muscles, but no study has been performed to investigate the reliability of MRE on lumbar muscles. The objective of this work was to determine the reliability of MRE techniques on lumbar muscles in both ex vivo phantom and in vivo human studies. In this study, fresh porcine leg muscles were used in the phantom study, and 80 healthy adults (38.
View Article and Find Full Text PDFBackground: Follicular lymphoma (FL) is less prevalent in Asians, but detailed epidemiological analyses were not available. This study aimed to characterize the epidemiologic features of FL in Taiwan to explore the factors relevant to disease development and prognosis.
Methods: We obtained epidemiological data for Taiwanese citizens during 1990-2012 from Taiwan's National Cancer Registry Database, and the corresponding data for US Caucasians from the Surveillance, Epidemiology, and End Results Program.
Purpose: To evaluate the prevalence of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in the illicit male ketamine abusers (KA).
Materials And Methods: The male street KAs caught by policemen and patients visiting urologic clinics were invited to answer a structured questionnaire including demographic data, illicit drug use related details (duration, frequency, dosage and abstinence status), international prostate symptoms score (IPSS), interstitial cystitis symptoms and problem index (ICSI and ICPI) and International index of erectile function (IIEF-5). Erectile dysfunction was defined as IIEF-5 ≦21.
Introduction: According to official statistics in Taiwan, the main body region of injury causing bicyclist deaths is the head, and bicyclists are 2.6 times more likely to be fatally injured than motorcyclists. There is currently a national helmet law for motorcyclists but not for bicyclists.
View Article and Find Full Text PDF[Effect of Dangua Recipe on Hepatic Adiponectin Receptor 2 Expression in Diabetic Apolipoprotein E Knockout Mice].
Zhongguo Zhong Xi Yi Jie He Za Zhi
September 2016
Objective To observe the effect of Dangua Recipe (DR) on adiponectin receptor 2 (AdipoR2) expression in liver of apolipoprotein E knockout (ApoE⁻¹⁻) diabetic mice. Methods Eight- week-old ApoE⁻¹⁻ mice were randomly divided into the model control group, the DR group, the pioglitazone group, and the combined treatment group. Besides, a C57 group was set up consisting of same age C57BL/ 6J mice.
View Article and Find Full Text PDFObjective: To study the effect of Dangua Recipe (DGR) on glycolipid metabolism, vascular cell adhesion molecule-1 (VCAM-1) and its mRNA expression level of transgenic Apo E(-/-) mouse with spontaneous atherosclerosis, thus revealing its partial mechanism for curing diabetes mellitus (DM) with angiopathy.
Methods: Diabetic model was prepared by peritoneally injecting streptozotocin (STZ) to Apo E(-/-) mouse. Totally 32 modeled mice were stratified by body weight, and then divided into 4 groups referring to blood glucose levels from low to high by random digit table, i.
Background: Clinical outcomes of intravenous (IV) infusion of zoledronic acid (ZOL) for lumbar interbody fusion surgery (LIFS) remain unknown. We investigated the efficacy of IV ZOL on clinical outcome and bone fusion after LIFS.
Materials And Methods: We retrospectively analyzed 64 patients with both degenerative lumbar spondylolisthesis and osteoporosis who underwent LIFS from January 2007 to April 2010.
Organic/Metallic nanohybrids based on amphiphilic dumbbell-shaped dendrimers.
ACS Appl Mater Interfaces
April 2012
In this study, we synthesized a series of amphiphilic dumbbell-shaped dendrimers through the addition reactions of a hydrophilic poly(oxyalkylene) with hydrophobic dendrons based on 4-isocyanate-4'-(3,3-dimethyl-2,4-dioxo-azetidine)diphenylmethane with different numbers of branching generations. The addition reaction of azetidine-2,4-diones of dendrons to amines of poly(oxyalkylene) was proceeded by stirring the reactants in dry tetrahydrofuran (THF) under nitrogen at 60 °C. In aqueous media, the dumbbell-shaped dendrimers self-assembled into micelles with their hydrophobic dendrons in the core and their hydrophilic poly(oxyalkylene) segments forming loops in the corona shell.
View Article and Find Full Text PDFPurpose: The aim of this study was to investigate the role of inflammatory biomarkers and total bile acid (TBA) in oral secretions in the development of ventilator-associated pneumonia (VAP).
Materials: This prospective study was conducted in an intensive care unit. Oral secretions were collected from mechanically ventilated patients who met the selection criteria for VAP prevention protocol.
Objective: To improve the biological properties of decellularized aortic valves by polyethylene glycol (PEG)-mediated covalent incorporation of vascular endothelial growth factor (VEGF).
Methods: PEG crosslinking of decellularized aortic valves were completed via a Michael-type addition reaction, followed by covalent incorporation of VEGF through another Michael-type addition reaction between the unsaturated propylene acyl of PEG and the thiol groups on cysteine residues of VEGF. The effect of VEGF incorporation was evaluated by enzyme-linked immunosorbent assay (ELISA) and immune fluorescence assay.
Background: This prospective study investigates recurrence rates and identifies predictive factors for recurrence following successful nonoperative treatment in adult patients with acute appendicitis.
Methods: Between January 2003 and December 2009, adult patients with acute appendicitis who received successful nonoperative management were enrolled. Cumulative recurrence rates were calculated using the Kaplan-Meier method.
Objective: To investigate the clinical importance of cytokines, surfactant protein D (SFTPD, formerly SP-D), and Kerbs von Lungren 6 antigen (KL-6) in bronchoalveolar lavage fluid (BALF) and blood in patients with idiopathic pulmonary alveolar proteinosis (iPAP).
Participants And Methods: Patients with iPAP diagnosed by characteristic cytopathologic examination of BALF and pathologic examination of transbronchial lung biopsy specimens or open lung biopsy specimens were enrolled in the study from January 1, 1995, through June 30, 2005. To investigate the clinical importance of cytokines, SFTPD, and KL-6 in iPAP, we measured tumor necrosis factor superfamily, member 2 (TNF, formerly TNF-alpha) and interleukin (IL) 1beta in BALF and IL-6, IL-10, IL-8, chemokine (C-C motif) ligand 4 (CCL4, formerly MIP-1beta), chemokine (C-C motif) ligand 2 (CCL2, formerly MCP-1), SFTPD, and KL-6 in both BALF and blood in 15 patients with iPAP and 48 patients with interstitial lung diseases (diseased controls) (including 20 with interstitial pneumonitis associated with collagen vascular diseases, 13 with idiopathic pulmonary fibrosis, and 15 with sarcoidosis) and 20 individuals without pulmonary diseases (lung controls).
Background: Effect of acute hypobaric hypoxia on autonomic nervous activities remains unclear. We evaluated the effect of rapid ascent to high altitude on autonomic cardiovascular modulation and compared the differences between the subjects with and without acute mountain sickness (AMS).
Method: Twenty-seven unacclimatized healthy subjects were included for this study.
Background: Repeated thoracenteses is indicated in patients with refractory, symptomatic transudative effusions. However, their effect on cytokines and fibrinolytic activity in pleural transudates remains unclear.
Methods: Twenty-one patients with symptomatic, large amount of free-flowing transudative effusions caused by heart failure were studied.
Study Objectives: To measure tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta, and transforming growth factor (TGF) beta1 in loculated and free-flowing pleural effusions caused by malignancy, tuberculosis (TB), and pneumonia and their relationship with plasminogen activator inhibitor-type 1 (PAI-1) and tissue-type plasminogen activator (tPA) and to compare the differences between loculated and free-flowing effusions.
Design: A prospective study.
Patients And Methods: The effusion levels of TNF-alpha, IL-1beta, TGF-beta1, PAI-1, and tPA were measured in 29 patients with malignant effusions, 19 patients with TB, and 30 patients with parapneumonic effusions.