Publications by authors named "Yi-chen Tang"
Article Synopsis
- Radical resection is the best treatment for hilar cholangiocarcinoma (HCCA), but its complexity makes surgical procedures challenging due to potential tumor invasion in critical vessels.
- This study analyzes the safety and effectiveness of laparoscopic versus open surgery for HCCA by reviewing data from 83 patients who had radical resections, resulting in a comparison of 32 open surgery patients and 16 laparoscopic patients.
- Key findings indicated that the laparoscopic approach resulted in less intraoperative blood loss and shorter operative time when compared to open surgery, although both surgical methods had comparable baseline characteristics and pathological outcomes.
Background: Multiple studies have demonstrated that neoadjuvant chemotherapy (NACT) can prolong the overall survival of pancreatic ductal adenocarcinoma (PDAC) patients. However, most studies have focused on open surgery following NACT.
Aim: To investigate the efficacy and safety of laparoscopic radical resection following NACT for PDAC.
Objective: To explore the association between a modified Blumgart anastomosis technique and the operative time and surgical complications.
Methods: This is a retrospective cohort study that analyzed the data of patients who underwent laparoscopic pancreaticoduodenectomy from January 2015 to March 2021. The primary outcome was to explore the association between the modified Blumgart anastomosis technique and operative time.
Background: The roles of immune checkpoint inhibitors in the treatment of gallbladder cancer are still unclear and challenged by controversial findings. Recent research has shown that immune checkpoint inhibitors in combination with chemotherapy may alleviate disease progression.
Case Summary: A 45-year-old female patient with gallbladder cancer accompanied by multiple abdominal lymph node metastasis was treated with camrelizumab combined with paclitaxel for injection (albumin-bound) and gemcitabine (AG) to downstage the tumor before a radical surgery could be performed.
Background: Laparoscopic pancreaticoduodenectomy (LPD) is widely used in several centers. This study analyzed the postoperative complications rate curve, possible cause, and solution of LPD and open pancreaticoduodenectomy (OPD).
Methods: Between January 2015 and December 2019, the study included 213 and 204 patients undergoing OPD and LPD, respectively.
Background: Endoscopic retrograde pancreatic drainage (ERPD) and stent implantation has become the major treatment method for pancreatic pseudocysts. However, it is associated with a high recurrence rate and infection.
Aim: To manage pancreatic pseudocysts by sequential therapy with endoscopic naso-pancreatic drainage (ENPD) combined with ERPD and evaluate the treatment outcome.
Article Synopsis
- The study focuses on the treatment of gallstones and choledocholithiasis using a combination of endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic cholecystectomy (LC), aiming to preserve gallbladder function and reduce injury risks.
- Six patients underwent the ERCP procedure, achieving a 100% success rate in stone removal, with only mild complications reported and an average hospital stay of 6.16 days.
- This innovative approach shows promising results for treating gallstones and choledocholithiasis and suggests further research into its application and safety.
Background: Hepatobiliary-pancreatic cancers (HBPs) are highly lethal, partly because of their usually late diagnosis. This multi-center, observational study aimed to explore the clinical significance of folate receptor-positive circulating tumor cell (FR+CTC) as a liquid biopsy approach in the differential diagnosis and management of HBPs.
Methods: We recruited 119 patients suspicious for HBPs and 60 cancer-free healthy individuals in the present study.
The correlation between nuclear factor-kappa B (NF-κB) and COMMD7 in hepatocellular carcinoma (HCC) development remained unclear. Here, our clinicopathological data showed that COMMD7 is overexpressed in HCC with a correlation to NF-κB. Using HepG2 and SMMC-7721 cells that aberrantly overexpressed COMMD7, we found that NF-κB directly binds with COMMD7 promoter and serves as an activator for COMMD7 transcription by luciferase reporter assay, chromatin immunoprecipitation (ChIP), and electrophoretic mobility shift assay (EMSA).
View Article and Find Full Text PDFHydrogen has been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases. The present study was designed to investigate the effect of hydrogen inhalation on liver ischemia/reperfusion (I/R) injury in rats. The portal triad to the left lobe and the left middle lobe of the liver were completely occluded for 90 min.
View Article and Find Full Text PDFBackground And Objective: Extramammary Paget's disease (EMPD) is a rare intra-epithelial neoplasm. Surgical excision is the treatment of choice. The usefulness of topical photodynamic therapy (PDT) in the treatment of EMPD has been reported.
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