CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p.

Osteosarcoma (OS) is a malignant bone tumour that commonly occurs in paediatric and adolescent patients. Currently, effective therapy for OS remains elusive due to poor patient survival rates. In this study, we observed significantly elevated expressions of circTUBA1C in OS tumours and cells.

Prognostic value of neutrophil to lymphocyte ratio and platelet counts during chemotherapy in patients with advanced gastric cancer.

Objectives: To investigate the predictive significance of dynamic changes in the neutrophil to lymphocyte ratio (NLR) and platelet counts (PLTs) in patients with advanced gastric cancer (GC) during chemotherapy.

Methods: A total of 259 advanced GC patients receiving chemotherapy were enrolled and grouped by high or low NLR with a cut value of 2.5 and PLT with cut value of 300×10/L.

Correlation Analysis between T790M Status and Clinical Characteristics of Patients with EGFR-sensitive Mutation Advanced NSCLC who Progressed after the First Generation and First-line EGFR-TKIs Administration: A Real-world Exploratory Study.

Aim: The present study is to investigate the association between T790M status and clinical characteristics of patients with EGFR-sensitive advanced non-small cell lung cancer (NSCLC) who progressed the initial epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKIs) administration.

Methods: A total of 167 patients with EGFR-sensitive mutations advanced NSCLC who had successful genetic tests and progressed the initial EGFR-TKI treatment were included in this study retrospectively. The clinical and demographic characteristics of these patients were collected, which were manifested as pathological type, metastasis location, initial biopsy method, initial genetic test specimens, and baseline gene mutations status.

Prognostic factors of primary neuroendocrine breast cancer: A population-based study.

Background: Primary neuroendocrine breast carcinomas (NEBCs) are an extremely rare and underrecognized subtype of mammalian carcinoma. The prognostic factors for NEBCs remain controversial.

Methods: In this multicenter retrospective study, the prognostic factors for patients with primary NEBCs who underwent surgery and had a pathologically confirmed diagnosis of neuroendocrine carcinoma in China and the United States were examined.

CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer.

Background: Primary colorectal cancer (PCRC) is a common digestive tract cancer in the elderly. However, the treatment effect of PCRC is still limited, and the long-term survival rate is low. Therefore, further exploring the pathogenesis of PCRC, and searching for specific molecular targets for diagnosis are the development trends of precise medical treatment, which have important clinical significance.

Assessment of MRI-based anomalous diffusion changes in brain ischemic stroke with a fractional motion model.

The actual diffusion process in human brain has been shown to be anomalous comparing to that predicted with traditional diffusion MRI (dMRI) theory. Recently, dMRI based on fractional motion (FM) model has demonstrated the potential to accurately describe anomalous diffusion in vivo. In this work, we explored the potential value of FM model-based dMRI in quantificational identification of ischemic stroke and compared that with the traditional apparent diffusion coefficient (ADC).

Differences of attentional networks function in athletes from open-skill sports: an functional near-infrared spectroscopy study.

Objective: The purpose of this study was to investigate the attentional networks function characteristics of interceptive and strategic sports athletes from open-skill sports.

Methods: We used a revised lateralized attention network task to measure attentional networks efficiency and activation related to flanker conflict effects, alerting effects, and orienting effects changes on the right frontoparietal network using functional near-infrared spectroscopy in 20 strategic sports athletes, 20 interceptive sports athletes, and 22 college students.

Results: The interceptive sports athletes had the fastest overall reaction time.

[Comparative analysis of two hybrid technique in treating multilevel cervical spondylotic myelopathy via anterior approach].

Objective: To compare the clinical effects and complications of two hybrid decompression techniques in treating multilevel (>=3) cervical spondylotic myelopathy(MCSM).

Methods: The clinical data of 124 patients with multilevel (>=3) cervical spondylotic myelopathy treated by surgery and follow-up from January 2008 to December 2016 were retrospectively analyzed. According to the different operative methods, the patients were divided into group A and group B.

[The continuous trophic spectrum of food web in Dalian marine area, China.].

This study analyzed the values of δC and δN by the application of stable isotope technique from the marine mammals (Phoca largha, Neophocaena asiaorientalis sunameri, Balaenoptera acutorostrata) and major biological species in Dalian marine area based on the animals collected due to stranding and death after bycatch from January, 2008 to June, 2017, and the fisheries resources investigation between autumn, 2016 and spring, 2017 in the same area. The trophic level was then calculated in order to establish the continuous trophic spectrum of the food web in Dalian marine area. The results showed that the value of δN ranged from 8.

Histone preconditioning protects against obstructive jaundice-induced liver injury in rats.

A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs from injury, and histones have been recently identified as DAMP molecules. The aim of the present study was to investigate the protective effect of histone preconditioning against OJ-induced liver injury in rats and the involvement of Toll-like receptors.

A direct competitive enzyme linked immunosorbent assay for progesterone using monoclonal antibody.

A direct competitive enzyme-linked immunosorbent assay (ELISA) with monoclonal antibody (MAb) was diagnosed with progesterone (P) level of human serum. In high concentrations and large amounts of displacer effect, this monoclonal antibody (MAb) can retain biological activity so that it can be specially combined with progesterone. Under conditions of the existing displaced agent, monoclonal antibody 11F8(3)H5 can maintain high specificity and affinity and can specifically bind progesterone in serum.

[Brain mappings in non-fluent late Chinese-English bilinguals].

Objective: To discuss the distribution characteristics of language areas in Chinese-English non-fluent late bilinguals.

Methods: Six Chinese-English bilinguals with eloquent tumors underwent awake-surgeries. The activated areas of BOLD-fMRI were obtained as the patients performed pure naming, verb generation, and abstract/concrete judgment tasks.

Chemiluminescence immunoassay for chloramphenicol.

In recent years, various chemiluminescent clinical immunoassay kits have been widely applied to the detection of hormones. However, a kit for chloramphenicol (CAP) is often absent from most commercial product lists, even though it is important to control the levels of CAP residues in foodstuffs too. Therefore, we describe a simple, solid-phase chemiluminescence immunoassay (CLIA) for the measurement of CAP in foodstuffs.