Publications by authors named "Yi-Zhou Mei"
Article Synopsis
- * ABT-888 was found to decrease SM-induced edema and necrosis, as well as alleviate energy depletion and cell death in HaCaT cells by downregulating apoptosis-related markers and improving cell viability.
- * However, caution is advised with PARP inhibitors like ABT-888, as they may inadvertently enhance DNA damage by increasing the phosphorylation of H2AX after SM exposure.
Background: In clinical studies, the findings on sulfur mustard (SM) toxicity for CD3(+)CD4(+) and CD3(+)CD8(+) T lymphocyte subsets are contradictory. In animal experiments, the effect of SM on the T cell number and proliferation is incompatible and is even the opposite of the results in human studies. In this study, we observed the dynamic changes of T lymphocytes in the first week in a high-dose SM-induced model.
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