Publications by authors named "Yi-Zhou Feng"
Article Synopsis
- Cardiac remodelling is a key factor in cardiovascular diseases, and this study investigates the role of TRAF7, a protein linked to heart defects, in promoting pathological cardiac hypertrophy.
- Researchers utilized mouse models and various experimental techniques to examine how TRAF7 affects heart cell growth and dysfunction, revealing that higher levels of TRAF7 worsen heart enlargement, while reducing TRAF7 has a protective effect.
- The study found that TRAF7 influences heart hypertrophy by interacting with another protein, ASK1, which leads to its activation and contributes to the disease process, suggesting that TRAF7 could be a potential target for new treatments.
Diabetic cardiomyopathy (DCM), one of the most serious long-term consequences of diabetes, is closely associated with oxidative stress, inflammation and apoptosis in the heart. MACRO domain containing 1 (Macrod1) is an ADP-ribosylhydrolase 1 that is highly enriched in mitochondria, participating in the pathogenesis of cardiovascular diseases. In this study, we investigated the role of Macrod1 in DCM.
View Article and Find Full Text PDFADP-ribosylation (ADPr) is a dynamically reversible post-translational modification (PTM) driven primarily by ADP-ribosyltransferases (ADPRTs or ARTs), which have ADP-ribosyl transfer activity. ADPr modification is involved in signaling pathways, DNA damage repair, metabolism, immunity, and inflammation. In recent years, several studies have revealed that new targets or treatments for tumors, cardiovascular diseases, neuromuscular diseases and infectious diseases can be explored by regulating ADPr.
View Article and Find Full Text PDFGrowing evidence indicates that neuroinflammation plays a critical role in anxiety, depression, and cognitive impairment. Sleep loss disrupts the host's immune balance and increases neuroinflammation. This study explored whether chronic sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression, and cognitive impairment and assessed the underlying mechanisms.
View Article and Find Full Text PDFPurpose: To investigate changes and links of stress and high sleep reactivity (H-SR) on the macro-structure and orderliness of sleep and cortisol levels in good sleepers (GS).
Patients And Methods: Sixty-two GS (18-40 years old) were recruited, with 32 in the stress group and 30 in the control group. Each group was further divided into H-SR and low SR subgroups based on the Ford Insomnia Response to Stress Test.
Article Synopsis
- * Resveratrol is a substance that can help reduce anxiety and depression and has other health benefits.
- * In the study, mice that were given resveratrol after being separated from their mothers showed less anxiety and depression, suggesting that resveratrol might help fix some of the problems caused by that separation.
Article Synopsis
- Early-life stress and maternal sleep deprivation in rodents negatively impact the development of the central nervous system, leading to risks of neuropsychiatric disorders in their offspring, even into old age.
- A study examined the effects of maternal sleep deprivation on depression and cognitive function in older CD-1 mice, finding that these mice displayed heightened depression-like behaviors and impaired cognition due to increased proinflammatory markers in the brain.
- However, long-term exposure to an enriched environment was shown to reverse these negative effects, improving neuroinflammation and synaptic plasticity, suggesting that environmental enrichment can mitigate the adverse impacts of maternal sleep deprivation.
Purpose: To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating factor [GM-CSF], and regulated on activation and normal T cell expressed and presumably secreted [RANTES]).
Patients And Methods: A total of 65 CID patients and 39 sex- and age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data on demographics, and were elevated sleep and mood by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), 17-item Hamilton Depression Rating Scale (HAMD-17) and 14-item Hamilton Anxiety Rating Scale (HAMA-14), respectively.