Publications by authors named "Yi-Yue Ren"
Am J Cancer Res
April 2021
Article Synopsis
- - Pinin (PNN) is a protein known to promote tumor growth in various cancers, such as ovarian and colorectal, and has now been found to be upregulated in prostate cancer as well, correlating with higher Gleason scores and advanced tumor stages.
- - The study revealed that PNN enhances prostate cancer cell growth and invasiveness by driving the transition from the G1 to S phase of the cell cycle, involving proteins like CDK6, CDK2, and Cyclin D1.
- - PNN also promotes cell migration and the epithelial-mesenchymal transition (EMT) in prostate cancer cells by activating the CREB pathway through PI3K/AKT and ERK/MAPK signaling, suggesting
