Publications by authors named "Yi-Yu Tsai"

To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients matched by sex, age, and index year.

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Dengue-related ocular complications were considered rare, but recent evidence points to a broader spectrum of manifestations, including uveitis. This study utilized the Taiwan National Health Insurance Research Database (NHIRD) to investigate the incidence of uveitis in dengue patients, aiming to fill this research gap. This population-based, retrospective cohort study utilized the Taiwan National Health Insurance Research Database (NHIRD) and included patients with and without Dengue fever.

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The risks of uveitis development among monkeypox (MPOX) patients are unclear. To determine the uveitis risks after (MPOX) diagnosis. Population-based, retrospective cohort study used the TriNetX database and recruited those with and without MPOX diagnosis from January 1, 2016, to December 31, 2023.

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Article Synopsis
  • This study explored the link between chronic kidney disease (CKD) and new diagnoses of glaucoma over a decade (2009-2019) using Taiwanese health records.
  • The research found that patients with CKD had a significantly higher risk of developing glaucoma, regardless of age, gender, or CKD subtype, compared to those without CKD.
  • Statistical analysis revealed consistent increases in glaucoma risk across various demographics, with hazard ratios indicating greater vulnerability among both genders and all age groups.
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Background: An impaired ocular surface presents substantial challenges in terms of planning for cataract surgery. As a multifactorial ocular disorder, dry eye disease (DED) is common in the general population and prevalent in patients scheduled for lens replacement surgery. Cataract surgery can exacerbate DED and worsen several ocular parameters.

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Importance: The long-term estimated risk of development of cataracts among pediatric patients with uveitis is not clear.

Objective: To describe factors associated with the development of cataracts among pediatric patients with uveitis.

Design, Setting, And Participants: This cohort study used the international TriNetX database to enroll pediatric patients with and without uveitis from January 1, 2002, to December 31, 2022.

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Corneal transplantation can restore visual function when visual impairment is caused by a corneal disease. However, this treatment is associated with the scarcity of cornea donors. The suitability of corneal donation from patients with glaucoma using ocular hypotensive agents (OHAs) is controversial.

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The risks of uveitis development among pediatric patients with Down syndrome (DS) remain unclear. Therefore, we aimed to determine the risk of uveitis following a diagnosis of DS. This multi-institutional retrospective cohort study utilized the TriNetX database to identify individuals aged 18 years and younger with and without a diagnosis of DS between 1 January 2000 and 31 December 2023.

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: The aim of this study was to synthesize the available evidence on the clinical efficacy of different relaxation exercises on intraocular pressure (IOP) reduction. : A systemic search of PubMed, Embase, Cochrane CENTRAL, and Web of Science was undertaken from the earliest record to 10 April 2024. Peer-reviewed studies that reported on healthy individuals and glaucoma patients engaging in relaxation exercises for at least three weeks were included.

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Purpose: To determine the risk of ptosis among diabetic retinopathy (DR) patients.

Methods: This is a population-based, retrospective, matched-cohort study where DR patients were recruited from the Taiwan National Health Insurance Research Database (NHIRD) to investigate the risk of developing ptosis. Preexisting co-factors of interest included smoking status and medical comorbidities of hyperlipidemia and hypertension.

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Objective: To explore the associations between the use of immune checkpoint inhibitors (ICIs) and the risk of developing uveitis among cancer patients.

Methods: Cancer patients who received ICI therapy and a comparison group of cancer patients who did not receive ICI therapy were retrospectively recruited from the TriNetX electronic heath-record registry. The outcome of interest was the development of new-onset uveitis.

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This is a case report of Epstein-Barr virus (EBV) uveitis confirmed via aqueous humor polymerase chain reaction (PCR) and metagenomics. This 72-year-old male with a history of diabetes and herpes zoster complained of redness and blurred vision in his right eye for eight months. Mild conjunctival injection, anterior chamber cells, mutton-fat keratic precipitates, and vitreous haze were noted.

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Few population-based studies have looked at the risk of uveitis among syphilis patients. Our study addresses the knowledge gap by reporting on uveitis risk in syphilis patients through a retrospective cohort study. The Taiwan National Health Insurance database was used for this study, covering the period from January 1st, 2009, to December 31st, 2020.

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Reports on uveitis after COVID-19 have been limited. Our objective was to examine the risk of uveitis among COVID-19 patients. This was a retrospective cohort study based on the TriNetX platform.

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To investigate the clinical efficacy of omidenepag isopropyl (OMDI) among glaucoma patients in terms of increased intraocular pressure (IOP) changes through a meta-analysis. Studies investigating the clinical efficacy of OMDI toward glaucoma patients were systemically searched. Inclusion criteria include recruiting studies that consisted of glaucoma or normal tension glaucoma patients who received OMDI treatment at least 4 weeks in duration.

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Article Synopsis
  • The study investigated the potential link between tinnitus (ringing in the ears) and uveitis (inflammation of the eye) due to shared autoimmune pathways.
  • It analyzed data from over 31,000 tinnitus patients compared to more than 124,000 individuals without tinnitus, from 2001 to 2018.
  • Results indicated that tinnitus patients have a significantly higher risk of developing uveitis, suggesting a possible association between the two conditions.
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Introduction: To investigate the association of blepharitis and ischemic stroke.

Methods: This nationwide retrospective cohort study used population-based data in Taiwan. Individuals aged 20 and above with diagnosis of blepharitis was included based on electrical medical records.

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Article Synopsis
  • - The study aimed to identify OCT-based biomarkers that can help predict treatment response in diabetic macular edema (DME) patients receiving intravitreal ranibizumab injections, which is crucial for customizing treatment plans.
  • - Researchers analyzed data from 65 eyes of 35 patients, tracking visual acuity, central retinal thickness, and other OCT features at various time points before and after treatment.
  • - Results showed that specific biomarkers like DRIL, LONLC, and SRF were significant predictors of visual and structural improvements, demonstrating the potential value of OCT biomarkers in managing DME.
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