Publications by authors named "Yi-Yu Qian"
Article Synopsis
- - The study investigates how poly(ADP-ribose) polymerase inhibitors (PARPis), known for causing synthetic lethality in tumor cells, also influence the tumor immune microenvironment (TIME) to help fight tumors, although the specifics are still unclear.
- - Researchers used T-cell receptor (TCR) sequencing and various imaging techniques on clinical samples and mouse models to explore immune responses triggered by PARPis, particularly focusing on a process called immunogenic cell death (ICD) linked to pyroptosis.
- - Results showed that PARPis increased TCR clonal expansion and promoted a more inflamed TIME with more immune cell infiltration, specifically highlighting pyroptosis as a critical mechanism through which PARPis activate the immune response against tumors
Colitis caused by infections, especially , has long been a common disease, underscoring the urgency to understand its intricate pathogenicity in colonic tissues for the development of effective anti-bacterial approaches. Of note, colonic epithelial cells, which form the first line of defense against bacteria, have received less attention, and the cross-talk between epithelial cells and bacteria requires further exploration. In this study, we revealed that the critical anti-bacterial effector, TFEB, was primarily located in colonic epithelial cells rather than macrophages.
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