[Evaluation of the maxillary basal bone and molar change of skeletal Class II malocclusion treated by sagittal-guidance Twin-block].

Purpose: To investigate the effects of sagittal-guidance Twin-block appliance on maxillary basal bone and buccal segment distalization in developing Angle Class II division 1 malocclusion.

Methods: The measurement data of anterior-posterior direction and vertical dimension between pretherapy and post-treatment, including 34 developing Angle Class II division 1 patients with sagittal-guidance Twin-block and non-extraction treatment, were quantitatively analyzed by X-ray cephalometry and Pancherz. SPSS 20.

Acyclovir skin depot characterization following in vivo iontophoretic delivery.

Background/purpose: Current Herpes labialis infection treatment by oral, parenteral or topical routes is inefficient. The objective of this study was to investigate the use of iontophoresis for improved topical delivery of acyclovir (ACV) in vivo in hairless rat.

Methods: Iontophoresis was performed for 10 min using a 5% ACV gel formulation.

Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin.

The objective of this study was to determine the effect of iontophoresis on the delivery of terbinafine hydrochloride (4%, w/w) into and across hairless rat skin. In vitro skin uptake and permeation studies were performed using Franz diffusion cells. Anodal iontophoresis was applied for 1h at current densities of 0.

Effects of disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets.

Effects of calcium silicate (disintegration-promoting agent) and various lubricants on an optimized beta-cyclodextrin-based fast-disintegrating tablet formulation were investigated. Effects of moisture treatment were also evaluated at 75, 85 and 95% relative humidities. A two factor, three levels (3(2)) full factorial design was used to optimize concentrations of calcium silicate and lubricant.