Publications by authors named "Yi-Xing Ren"
Article Synopsis
- This study focuses on creating a prognostic signature for early-stage triple-negative breast cancer (TNBC) patients to better assess their risk of distant recurrence.
- Researchers analyzed RNA-sequencing data from 189 TNBC patients and identified a set of 21 mRNAs linked to survival, from which they developed a 7-mRNA signature that proved effective in predicting recurrence risk.
- The signature includes mRNAs that not only predict outcomes but also highlight potential new targets for therapy, making it a useful tool for personalized treatment strategies in early-stage TNBC patients.
Background: Gastrointestinal stromal tumors are lesions that originate from digestive tract walls. Several laparoscopic techniques, including local resections, wedge resections and partial gastrectomies, have been used successfully. However, there are no reports on laparoscopic segmental gastrectomy for gastrointestinal stromal tumors.
View Article and Find Full Text PDFHuman endogenous retroviruses (HERVs) play pivotal roles in the development of breast cancer. However, the detailed mechanisms of noncoding HERVs remain elusive. Here, our genome-wide transcriptome analysis of HERVs revealed that a primate long noncoding RNA, which we dubbed TROJAN, was highly expressed in human triple-negative breast cancer (TNBC).
View Article and Find Full Text PDFArticle Synopsis
- * We categorized TNBCs into four subtypes based on their transcriptome: luminal androgen receptor (LAR), immunomodulatory, basal-like immune-suppressed, and mesenchymal-like, each with potential therapeutic targets and biomarkers.
- * Notably, the LAR subtype had distinct genetic features, including more ERBB2 mutations, rare mutational signature 3, and frequent loss of CDKN2A, which could assist in the tailored
Objectives: Patients with T1N0M0 breast cancers are considered to have an excellent prognosis, even in triple-negative breast cancer (TNBC), which is often associated with diminished recurrence-free survival (RFS) and overall survival. Chemotherapy remains the only adjuvant treatment for TNBC, but evidence that adjuvant chemotherapy is beneficial for stage T1N0M0 TNBC patients is limited. In this study, we aimed to evaluate the effect of adjuvant chemotherapy and the benefit of taxanes in T1N0M0 TNBC patients.
View Article and Find Full Text PDF[Treatment for severe rectal prolapse by laparoscopic rectopexy].
Zhonghua Wei Chang Wai Ke Za Zhi
November 2007
Objective: To evaluate the clinical practice of laparoscopic rectopexy in the treatment of severe rectal prolapse.
Methods: From March 1998 to February 2007, 4 cases of complete rectal prolapse, including 1 male and 3 female,ranged 21-82 years old, were treated by laparoscopic rectopexy. In one case, the posterior wall of rectum was freed and elevated, and pre-rectal introcession was closed by silk suture, then the posterior wall was suspended and fixed on sacral promontory fascia, finally the sigmoid colon was fixed by sutures on the fascia of left psoas major.