Publications by Yi-Xin Wen

Publications by authors named "Yi-Xin Wen"

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E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.

Qing Deng Qun Wang Wei-Ying Zong Da-Li Zheng Yi-Xin Wen

Cancer Res

January 2010

The E2F family member of transcription factors includes the atypical member E2F8, which has been little studied in cancer. We report that E2F8 is strongly upregulated in human hepatocellular carcinoma (HCC), where it was evidenced to contribute to oncogenesis and progression. Ectopic overexpression of E2F8 promoted cell proliferation, colony formation, and tumorigenicity, whereas E2F8 knockdown inhibited these phenotypes, as documented in Huh-7, Focus, Hep3B, and YY-8103 HCC cell lines.

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- Yi-Xin Wen's recent research primarily focuses on the role of E2F8, a member of the E2F family of transcription factors, in human hepatocellular carcinoma (HCC).
- The study found that E2F8 is significantly upregulated in HCC, contributing to oncogenesis, progression, and various tumor-promoting characteristics such as cell proliferation and colony formation.
- Experimental evidence demonstrated that overexpression of E2F8 enhances tumorigenic behavior in several HCC cell lines, while its knockdown effectively inhibits these phenotypes, suggesting a potential target for therapeutic intervention in HCC.

Publications by authors named "Yi-Xin Wen"

E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.

Synopsis of recent research by authors named "Yi-Xin Wen"