Circularly polarized luminescence of pinene-modified tetradentate platinum(II) enantiomers containing fused 5/6/6 metallocycles.

In this study, a couple of tetradentate Pt(II) enantiomers ((-)- and (+)-) and a couple of tetradentate Pt(IV) enantiomers ((-)- and (+)-) containing fused 5/6/6 metallocycles have been synthesized by controlling reaction conditions. Two valence forms could transform into each other through mild chemical oxidants and reductants. Single-crystal X-ray diffraction confirms the structures of (-)-1 and (-)-2.

Ultrasound targeted microbubble destruction for novel dual targeting of HSP72 and HSC70 in prostate cancer.

The aim was to determine whether ultrasound targeted microbubble destruction (UTMD) promotes dual targeting of HSP72 and HSC70 for therapy of castration-resistant prostate cancer (CRPC), to improve the specific and efficient delivery of siRNA, to induce tumor cell specific apoptosis, and to find new therapeutic targets specific of CRPC.VCaP cells were transfected with siRNA oligonucleotides. HSP70, HSP90 and cleaved caspase-3 expression were determined by real-time quantitative polymerase chain reaction and Western blotting.

Stereotactic body radiation therapy favors long-term overall survival in patients with lung metastases: five-year experience of a single-institution.

Background: Metastatic lung cancer is one of the most common oncologic problems. This study aimed to evaluate the long-term clinical outcome of stereotactic body radiation therapy (SBRT) for metastatic lung tumors.

Methods: We retrospectively reviewed the 71 patients with lung metastases, who had 172 lesions treated with SBRT from January 2000 to December 2006.

[Candida species distribution in the patients with high risk of deep fungal infections and relevant risk factors: a prospective cohort study].

Objective: To study the distribution of Candida spp. in the patients with high-risk of fungal infection and the risk factors of deep candidiasis.

Methods: A prospective cohort study was performed among 440 consecutive hospitalized patients admitted to the hematology wards, geriatric wards, and ICUs from May 2004 to April 2005.

[Efficiency of APACHE II and III scoring system in the prognostication of patients older than 75 years].

Objective: To observe the efficiency of both the APACHE II/III scoring systems in predicting the prognosis of patients older than 75 years.

Methods: We calculated both the APACHE II and III scores in patients older than 75 years who were admitted to the geriatric intensive care unit (GICU) of our hospital in a duration of 6 months. The scores and predicting death rates were compared with the actual death rates.