Publications by authors named "Yi-Tung Tsai"
Background: Prolonged exposure to sun radiation may result in harmful skin photoaging. Therefore, discovering novel anti-photoaging treatment modalities is critical. An active component isolated from Salvia miltiorrhiza (SM), Salvianolic acid B (Sal-B), is a robust antioxidant and anti-inflammatory agent.
View Article and Find Full Text PDFSalvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro.
Aesthetic Plast Surg
August 2023
Background: Hypertrophic scars (HTSs) are a fibroproliferative disorder that occur following skin injuries. Salvianolic acid B (Sal-B) is an extractant from Salvia miltiorrhiza that has been reported to ameliorate fibrosis in multiple organs. However, the antifibrotic effect on HTSs remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- The urothelium, which lines the bladder and other urinary structures, relies on stem cells for maintenance and has potential for cell therapy to fix damage caused by various stresses, leading to conditions like cystitis.
- This study explores using porcine urothelial cells (PUCs) as a treatment for cystitis by introducing them directly into the bladder, showing that they can shield the urothelium from harmful chemical damage and reduce inflammation in a mouse model.
- Although PUC treatment was effective in maintaining the integrity of the bladder lining, it did trigger some immune responses, indicating a balance between potential benefits and the body’s reaction to foreign cells.
Background: Crude extract of breadfruit has been reported to have antitumor activity against various cancer cell lines with unknown mechanism.
Purpose: This study aims to investigate the proapoptotic effect of cyclocommunol (CYC), a prenylflavonoid from breadfruit, in two oral squamous cell carcinoma (OSCC) cell lines, SCC2095 and Ca922.
Methods: The antiproliferative effects of CYC were assessed by MTT assays and PI/annexin V analysis.
Background/aim: Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC.
Materials And Methods: The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. Next, we used the Taiwan National Health Insurance Research database to conduct a population-based case-control study to investigate the effect of a 5-ARI, finasteride on UBC incidence.