Publications by authors named "Yi-Ting T Wang"
Background And Objectives: To compare the diagnostic performance of an immunoassay for plasma concentrations of phosphorylated tau (p-tau) 217 with visual assessments of fluorine-18 fluorodeoxyglucose [F]FDG-PET in individuals who meet appropriate use criteria for Alzheimer dementia (AD) biomarker assessments.
Methods: We performed a retrospective analysis of individuals with early-onset (age <65 years at onset) and/or atypical dementia (features other than memory at onset), who were evaluated at a tertiary care memory clinic. All participants underwent measurements of CSF biomarkers (Aβ42, p-tau181, and total tau levels), as well as [F]FDG-PET scans, amyloid-PET scans, and plasma p-tau217 quantifications.
Article Synopsis
- The review focuses on the latest advancements in brain imaging techniques, particularly for diagnosing Alzheimer's disease (AD).
- Recent developments like FDA approval of new anti-amyloid therapies highlight the importance of amyloid-PET imaging in treatment planning, while tau-PET imaging is crucial for tracking disease progression.
- Emerging techniques and AI applications in MRI show promise for early AD detection, though further research is needed for clinical validation.
The apolipoprotein E gene () is the most important genetic risk factor for sporadic Alzheimer disease, with the allele being associated with increased cerebral amyloid-β and tau pathologies. Although has been suggested to have a stronger effect in women as compared to men, there is a lack of comprehensive assessment on how the interactive effect of and sex modulates regional vulnerability to tau accumulation. We previously have shown the regional vulnerability to the interactive effect of tau and , yet the sex difference was not specifically addressed.
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