C-FLIP Modulated Wnt/β-Catenin Activation via Association with TIP49 Protein.

Cellular FLICE-like inhibitory protein (c-FLIP) is a key inhibitory protein in the extrinsic apoptotic pathway. Recent studies showed that c-FLIP could translocate into the nucleus and might be involved in the Wnt signaling pathway. The nuclear function of c-FLIP was still unclear.