Publications by authors named "Yi-Tang Chen"

Background: Although the publication of randomized clinical trials defining the benefit of carotid endarterectomy (CEA) for asymptomatic carotid stenosis, medical management of carotid stenosis has changed significantly. With antiplatelet agents and statins, some question whether these trials are still relevant, suggesting that asymptomatic patients with >70% internal carotid artery (ICA) stenosis may do better with medial management alone, lessening the need for CEA and carotid stenting. The Vascular Quality Initiative (VQI) registry has shown that there are wide practice variations regarding the degree of stenosis that prompts surgical intervention but there are few reports of outcomes in patients who do not undergo intervention.

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The growth, biomass, nutrient content and accumulation as well as the vertical distribution of nutrient accumulation in plantation across densities of 1800, 3000, 4500 trees·hm were stu-died in order to provide scientific basis for efficient cultivation of plantation. The total amounts of nutrients accumulated in plantation with 1800, 3000, 4500 trees·hm were 1311.57, 2531.

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Background: Insufficient social support is associated with increased mortality among older adults. Lung cancer is primarily a disease of older adults and is the leading cause of all cancer deaths. We assessed the association of social support with outcomes among older adults with lung cancer.

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Unlabelled: To use latent class growth analysis to identify posttraumatic stress disorder symptom trajectories in ICU family caregivers.

Design: Prospective cohort study.

Setting: The medical ICU at a tertiary-care center in the United States.

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Article Synopsis
  • The study aimed to compare the severity of symptoms and how much those symptoms interfere with daily life between younger (<65 years) and older (≥65 years) women undergoing similar chemotherapy for early breast cancer (EBC).* -
  • The results showed that younger women reported higher rates of severe hot flashes and myalgia, but overall, there were no significant differences in hospitalizations, dose adjustments, or treatment discontinuations between the two age groups.* -
  • The conclusion suggests that both age groups experienced similar levels of symptom severity and related issues, indicating that age may not significantly influence the impact of chemotherapy on women with EBC.*
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Background: Depression and anxiety are common in patients with breast cancer and associated with worse quality of life and treatment outcomes. Yet, these symptoms are often underrecognized and undermanaged in oncology practice. The objective of this study was to describe depression and anxiety severity and associated patient factors during adjuvant or neoadjuvant chemotherapy in women with early breast cancer using repeated single-item reports.

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Article Synopsis
  • The study compares patient-reported symptoms with clinician-reported toxicity in women undergoing chemotherapy for early-stage breast cancer, highlighting discrepancies in their reports.
  • Of the 267 participants, there was moderate to slight agreement between patient and clinician reports for various symptoms, with patients often reporting more severe symptoms than clinicians noted.
  • The findings underscore the need for incorporating patient-reported outcomes in cancer care to better monitor and address treatment-related symptoms.
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Background: Dietary inflammatory potential could impact the presence and severity of chronic adverse treatment effects among patients with head and neck cancer. The objective of this study was to determine whether pretreatment dietary patterns are associated with nutrition impact symptoms (NIS) as self-reported 1 year after diagnosis.

Methods: This was a longitudinal study of 336 patients with newly diagnosed head and neck cancer enrolled in the University of Michigan Head and Neck Specialized Program of Research Excellence.

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Background: Higher intakes of cruciferous vegetables (CVs) and green leafy vegetables (GLVs) in observational studies are associated with improvements in survival and cancer-related biomarkers in patients diagnosed with head and neck cancer (HNC). These results have yet to be corroborated in a randomized clinical trial (RCT).

Objective: Determine the feasibility of implementing a 12-week RCT to increase CV and GLV intake in posttreatment HNC survivors.

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No studies have evaluated associations between carbohydrate intake and head and neck squamous cell carcinoma (HNSCC) prognosis. We prospectively examined associations between pre- and post-treatment carbohydrate intake and recurrence, all-cause mortality, and HNSCC-specific mortality in a cohort of 414 newly diagnosed HNSCC patients. All participants completed pre- and post-treatment Food Frequency Questionnaires (FFQs) and epidemiologic surveys.

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Langmuir-Blodgett monolayers of thiolated gold nanoparticles mixed with dipalmitoylphosphatidylcholine/sodium dodecyl sulfate (DPPC/SDS) were investigated by combining the X-ray reflectivity, grazing-incident scattering, and TEM analyses to reveal the in-depth and in-plane organization and the 2D morphology of such mixed monolayers. It was found that the addition of a charged single-tail surfactant to the thiolated Au nanoparticle monolayer helps to stabilize the Au nanoparticle monolayer and to strengthen the mechanical property of the mixed monolayer film. For mixing with lipids, it was found that the thiolated gold nanoparticles could be pushed on top of the lipid monolayer when the mixed monolayer is compressed.

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