Publications by authors named "Yi-Tan Li"
Emergence of eravacycline heteroresistance in carbapenem-resistant isolates in China.
Front Cell Infect Microbiol
April 2024
Article Synopsis
- Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a challenge to antibiotic treatment, but eravacycline shows promise as a potential treatment option; however, its resistance mechanisms remain unclear.
- A study of 287 CRAB isolates from China identified that approximately 17% exhibited heteroresistance to eravacycline, mainly among strains that also produced the OXA-23 carbapenemase, with a significant correlation to higher expression levels of certain resistance genes.
- The study found that the presence of efflux pump inhibitors could reduce eravacycline resistance, indicating potential avenues for improving treatment strategies against CRAB infections. *
Natural spider silks with striking performances achieve extensive investigations. Nonetheless, a lack of consensus over the mechanism of the natural spinning hinders the development of artificial spinning methods where the regenerated spider silks generally show poor performances compared with the natural fibers. As is known, the Plateau-Rayleigh instability tends to break solution column into droplets and is considered a main challenge during fiber-spinning.
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