CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy.

Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are the main treatment modalities for OC.

Congenital dysfibrinogenemia misdiagnosed and inappropriately treated as acute fatty liver in pregnancy: A case report and review of literature.

Background: The purpose of this study was to report the rare case of a pregnant woman with congenital dysfibrinogenemia (CD) misdiagnosed as acute fatty liver. She was treated according to the principles of acute fatty liver but achieved good clinical results.

Case Summary: A 30-year-old woman presented with 39 (6/7) wk of menopause and 6 h of irregular abdominal pain and attended our hospital.

MutL homolog 1 germline mutation c.(453+1_454-1)_(545+1_546-1)del identified in lynch syndrome: A case report and review of literature.

Background: Lynch syndrome (LS) is an autosomal dominant hereditary disorder because of germline mutations in DNA mismatch repair genes, such as MutL homolog 1 (), PMS1 homolog 2, MutS homolog 2, and MutS homolog 6. Gene mutations could make individuals and their families more susceptible to experiencing various malignant tumors. In Chinese, germline mutation c.

Facile Strategy for Efficient Charge Separation and High Photoactivity of Mixed-Linker MOFs.

Two new sets of UiO-Zr metal-organic framework (MOF) bearing mixed linkers and that have different band gaps and edges were prepared through post oxidation and direct methods, namely, ( = 4, 9, 12 oxidation hours) and ( = 0, 0.4, 0.6, 2), respectively.

ortho-Heterofluorene perylenediimides: synthesis, photophysical, and exciton dynamic properties.

Previous studies suggest the perylenediimide (PDI) triplet excited state (T) have been accessible only through bimolecular sensitization, the internal heavy-atom effect or a sophisticated cascade of nonradiative processes. Here, we designed heavy-atom-free PDIs to prompt the T ← S intersystem crossing (ISC) by introducing electron donating heterofluorene groups at the head positions of the electron-deficient PDI core. We obtained relatively high ISC efficiency up to 92% yield.

Heterovalent-Doping-Enabled Efficient Dopant Luminescence and Controllable Electronic Impurity Via a New Strategy of Preparing II-VI Nanocrystals.

Substitutional heterovalent doping represents an effective method to control the optical and electronic properties of nanocrystals (NCs). Highly monodisperse II-VI NCs with deep substitutional dopants are presented. The NCs exhibit stable, dominant, and strong dopant fluorescence, and control over n- and p-type electronic impurities is achieved.

Role of ligand-to-metal charge transfer state in nontriplet photosensitization of luminescent europium complex.

We have investigated, by means of steady-state and time-resolved optical spectroscopies, the excited-state dynamics of the luminescent europium complex Eu(III)(tta)(3)dpbt (tta = henoyltrifluoroacetonate; dbpt = 2-(N,N-diethylanilin-4-yl)-4,6-bis(3,5-dimethylpyrazol-1-yl)-1,3,5-triazine) with Gd(III)(tta)(3)dpbt and Tb(III)(tta)(3)dpbt as the reference complexes that cannot be photosensitized. In the Eu(III)(tta)(3)dpbt complex, the ligand dpbt exhibited biphasic fluorescence decay kinetics; the faster component (decay time constant, 8.5 ps) is ascribed to the rapid conversion of the lowest-lying singlet excited state of dpbt (S(1) or (1)dpbt*) to a ligand-to-metal charge transfer singlet state of the complex ((1)LMCT*), whereas the slower one (1.

Excitation dynamics of two spectral forms of the core complexes from photosynthetic bacterium Thermochromatium tepidum.

The intact core antenna-reaction center (LH1-RC) core complex of thermophilic photosynthetic bacterium Thermochromatium (Tch.) tepidum is peculiar in its long-wavelength LH1-Q(y) absorption (915 nm). We have attempted comparative studies on the excitation dynamics of bacteriochlorophyll (BChl) and carotenoid (Car) between the intact core complex and the EDTA-treated one with the Q(y) absorption at 889 nm.

Interplay between the keto defect and the interchain interaction on the green emission of fluorene-based polymer.

To investigate the interplay between on-chain keto defect and interchain interaction and its consequence on the blue emission of polyfluorene (PF), first- to third-generation dendronized PFs as well as single-fluorenone-unit doped PF (PFN), synthesized by Suzuki polycondensation, were used as model compounds for steady-state and picosecond time-resolved photoluminescence (PL) spectroscopic studies. For PF film, the broad-band green emission did not appear, although severe interchain interaction was observed. For PFN film, the green emission that peaked at approximately 540 nm decayed in a multiphasic manner, suggesting significant heterogeneity in the excitation migration toward the keto center.

Mechanism of radical cation formation from the excited states of zeaxanthin and astaxanthin in chloroform.

The C-40 xanthophylls zeaxanthin and astaxanthin were confirmed to form radical cations, Car.+, in the electron-accepting solvent chloroform by direct excitation using subpicosecond time-resolved absorption spectroscopy in combination with spectroelectrochemical determination of the near-infrared absorption of Car.+.

Ultrafast carotenoid-to-chlorophyll singlet energy transfer in the cytochrome b6f complex from Bryopsis corticulans.

Ultrafast carotenoid-to-chlorophyll (Car-to-Chl) singlet excitation energy transfer in the cytochrome b(6)f (Cyt b(6)f) complex from Bryopsis corticulans is investigated by the use of femtosecond time-resolved absorption spectroscopy. For all-trans-alpha-carotene free in n-hexane, the lifetimes of the two low-lying singlet excited states, S(1)(2A(g)(-)) and S(2)(1B(u)(+)), are determined to be 14.3 +/- 0.

Triplet Excitation Transfer between Carotenoids in the LH2 Complex from Photosynthetic Bacterium Rhodopseudomonas palustris.

We have studied, by means of sub-microsecond time-resolved absorption spectroscopy, the triplet-excited state dynamics of carotenoids (Cars) in the intermediate-light adapted LH2 complex (ML-LH2) from Rhodopseudomonas palustris containing Cars with different numbers of conjugated double bonds. Following pulsed photo-excitation at 590 nm at room temperature, rapid spectral equilibration was observed either as a red shift of the isosbestic wavelength on a time scale of 0.6-1.

Protein structural deformation induced lifetime shortening of photosynthetic bacteria light-harvesting complex LH2 excited state.

Photosynthetic bacterial light-harvesting antenna complex LH2 was immobilized on the surface of TiO(2) nanoparticles in the colloidal solution. The LH2/TiO(2) assembly was investigated by the time-resolved spectroscopic methods. The excited-state lifetimes for carotenoid-containing and carotenoidless LH2 have been measured, showing a decrease in the excited-state lifetime of B850 when LH2 was immobilized on TiO(2).

Radical cation generation from singlet and triplet excited states of all-trans-lycopene in chloroform.

On direct photoexcitation, subpicosecond time-resolved absorption spectroscopy revealed that the 1B(u)-type singlet excited state of all-trans-lycopene in chloroform was about seven times more efficient than all-trans-beta-carotene in generating the radical cation. The time constant of radical cation generation from the 1B(u)-type state was found to be approximately 0.14 ps, a value that was comparable for the two carotenoids.