[A pilot study of ocular diseases screening for neonates in China].

Objective: To explore the clinical strategies for the screening of newborn eye diseases and obtain information concerning the incidence of newborn ocular diseases.

Methods: Newborns in a baby-friendly nursery were evaluated for mass screening of eye diseases 2 to 7 days after birth (including reaction to light stimulation, external ocular examination and test for pupil red reflex) and those with abnormalities were subjected to diagnostic examination (external ocular examination with a hand-held slit-lamp, pupil red reflex and mydriatic examination). Newborns in neonatal intensive care unit (NICU) were subjected to screening 5 to 14 days after birth and then, together with those with high risk factors, received a comprehensive examination for screening and diagnostic purposes.

[Simultaneous screening program for newborns hearing and ocular diseases].

Objective: To explore the model and the feasibility of newborn hearing and ocular disease simultaneous screening program and to study the birth prevalence of newborn hearing loss and newborn ocular diseases.

Methods: The universal newborn hearing screening (UNHS) was performed using transient otoacoustic emission (TEOAE) in well baby nursery and by a two-stage TEOAE and auto auditory brainstem response (AABR) protocol in neonatal intensive care unit (NICU). The UNHS was simultaneous done with newborn ocular disease screening program.

[Mutations of GJB2 gene in infants with non-syndromic hearing impairment].

Objective: To explore the relationship between GJB2 gene mutations and severe-to-profound bilateral non-syndromic hearing impairment (NSHI).

Methods: Peripheral blood was collected from 20 infants with severe-to-profound bilateral NSHI confirmed by otoacoustic emissions (OAE), auditory brainstem responses (ABR) and clinical physical examination, 11 male and 9 female, aged 3 months to 3 years. PCR and sequencing technique were used to analyze the coding region of GJB2 gene.

[Diagnosis and following-up and analysis of pathogenesis for congenital hearing loss].

Objective: To investigate the incidence and the relevant high-risk factors of congenital hearing loss for infants from well-baby nursery and newborn intensive care unit. To explore the scientific and feasible mode of early diagnosis, following-up and early intervention.

Methods: Two-stage universal newborn hearing screening ( UNHS ) were performed by using transient otoacoustic emission ( TEOAE ).

GJB2 gene mutations in newborns with non-syndromic hearing impairment in Northern China.

Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilateral severe-to-profound non-syndromic hearing impairment (NSHI) who were found at birth through newborn hearing screening and clinical examination is reported.

[The exploratory study of auto-auditory brainstem response in the high-risk infants on hearing screening].

Objective: To compare the pass rate of auto-auditory brainstem response (AABR) in infants complicated with different high-risk factors.

Methods: 245 infants (488 ears) with different high-risk factors, including premature, low-weight, hyperbilirubinemia, asphyxiation and pulmonary diseases, were tested by transiently evoked otoacoustic emission (TEOAE) and AABR at the same time.

Results: The pass rate of AABR and that of TEOAE were different for the infants with different high-risk factors.

[Flash visual evoked potentials on newborns and infants].

Objective: To explore the feasibility of applying flash visual evoked potentials (FVEPs) for visual function test newborns and infants and bring out the consultable laboratory values of FVEPs. The technology of FVEP could be used as diagnostic tests for those who failed the screening and the infants who were cared for in the NICU.

Methods: 41 normal neonates ( View Article and Find Full Text PDF

[A study on the risk indicators of newborn hearing loss].

Objective: To explore the risk indicators of newborn hearing loss.

Methods: Statistic description was used to analyze the basic characteristics of 41 hearing loss infants screened from 8,262 newborns; one way analysis was used by 1:2 matched case control study to analyze the risk indicators of newborns with hearing loss; chi-square test and multivariate condition Logistic stepwise regression mode were also used to find risk the indicators.

Results: By one way analysis, there were 3 high risk indicators associated with newborn hearing loss: family history of hearing loss, craniofacial anomalies, and NICU care history.

[A preliminary study of synchronous evoked potential in newborn-infant auditory and visual function test].

Objective: The purpose of this study is to bring out the consultable laboratory values of synchronous evoked potential in normal neonates and infants, investigate the characteristic of the electric response waveform, and explore its feasibility on applying to newborn auditory and visual function test as an electric physiology detection method.

Methods: It was applied to go on measuring 19 cases of mature normal neonate (< or =4 days) and 11 cases of infants (< or =5 months), also comparing with the study of ABRs, FVEPs independently.

Results: Get the electric response wave form results of synchronous electric evoked potential in both groups of newborn-infants, through comparing with the result of independent ABRs and FVEPs, the monitoring result demonstrated that there were an extreme significant changes of the corresponding parameters (wave I, III, V latency) (P<0.

[Hearing screening of 10,501 newborns].

Objective: To investigate the results of hearing screening in newborns so as to explore the appropriate clinical strategy of hearing screening among newborns.

Methods: Transiently evoked otoacoustic emission (TEOAE) was used to examine the hearing of 10,501 newborns 2 - 4 days after birth. Those who failed the initial screening underwent secondary screening with TEOAE.