Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders.

Objective: We previously reported that dual injections of lipopolysaccharide (LPS) in mice constitute a valuable tool for investigating the contribution of inflammation to psychotic disorders. The present study investigated how immune activation affects the kynurenine pathway and rat behaviour of relevance for psychotic disorders.

Methods: Male Sprague Dawley rats were treated with either dual injections of LPS (0.