Publications by authors named "Yi-Ran Guo"

Article Synopsis
  • Dental pulp stem cells (DPSCs) have potential for nerve repair, but the specifics of how they differentiate into neural cells need more exploration, particularly regarding the Wnt signaling pathways.
  • This study focused on the Wnt/Ca pathway's role in differentiating human DPSCs into neural cells and how it affects the Wnt/β-catenin pathway, involving experiments with neurogenic induction and various molecular assays.
  • Results indicated that Wnt/Ca pathway activity decreased during neurogenic induction, leading to increased signaling through the Wnt/β-catenin pathway and promoting higher levels of neural differentiation in the DPSCs. *
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Total triterpenoids from the fruits of Chaenomeles speciosa(TCS) are active components in the prevention and treatment of gastric mucosal damage, which have potential anti-aging effects. However, it is still unclear whether TCS can improve gastric aging, especially its molecular mechanism against gastric aging. On this basis, this study explored the effect and mechanism of TCS on senescent GES-1 cells induced by D-galactose(D-gal) to provide scientific data for the clinical use of TCS to prevent gastric aging.

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Ethnopharmacological Relevance: The leaves of Sapium sebiferum have long been used in Traditional Chinese Medicine (TCM) for the treatment of eczema, shingles, edema, swelling, ascites, scabs, and snakebites, among other maladies.

Aim Of This Study: The present study aimed to investigate the antioxidant and anti-inflammatory effects of the phenolic extracts of Sapium sebiferum leaves using in vitro and in vivo models.

Materials And Methods: The in vitro antioxidant activities of the extracts were measured using common chemical methods (total phenolic content; total flavonoid content; scavenging of DPPH·, ABTS+·, superoxide, and nitrite radicals; reducing power; β-carotene bleaching; and FTC assays).

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NADPH:protochlorophyllide (Pchlide) oxidoreductase (POR) is the key enzyme in the light-induced greening of higher plants. A unique light-harvesting POR:Pchlide complexes (LHPP) has been found in barley etioplasts, but not in other plant species. Why PORs from barley, but not from other plants, can form LHPP? And its function is not well understood.

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