[Facial soft tissue changes after full-arch implant-supported fixed prostheses restoration in patients with edentulous maxilla].

Purpose: To investigate the changes of nasolabial soft tissues before and after full-arch implant supported fixed restoration in maxillary edentulous patients and the influencing factors of the changes.

Methods: Fifty patients who underwent full-arch implant fixed restoration in the Department of Second Dental Center of Shanghai Ninth People's Hospital from January 2016 to July 2023 were selected. Patient's medical history, CBCT, and three-dimensional facial scan data were collected before and after restoration.

[Effect of EPA on inflammatory response of human periodontal ligament fibroblasts induced by P. gingivalis LPS].

Purpose: To observe the effect of eicosapentaenoc acid (EPA) on the expression of inflammatory factors in human periodontal ligament fibroblasts (hPDLCs) induced by using lipopolysaccharides (LPS) of Porphyromonas gingivalis (P. gingivalis).

Methods: hPDLCs were cultured by using tissue block method, and the effects of different concentrations of EPA on the activity of hPDLCs cells were observed by MTT method.

3D reconstruction for maxillary anterior tooth crown based on shape and pose estimation networks.

Purpose: The design of a maxillary anterior tooth crown is crucial to post-treatment aesthetic appearance. Currently, the design is performed manually or by semi-automatic methods, both of which are time-consuming. As such, automatic methods could improve efficiency, but existing automatic methods ignore the relationships among crowns and are primarily used for occlusal surface reconstruction.

Two novel ectodysplasin A gene mutations and prenatal diagnosis of X-linked hypohidrotic ectodermal dysplasia.

Background: Hypohidrotic ectodermal dysplasia (HED) is mainly caused by ectodysplasin A (EDA) gene mutation. Fetus with genetic deficiency of EDA can be prenatally corrected. This study aimed at revealing the pathogenesis of two HED families and making a prenatal diagnosis for one pregnant female carrier.

An image-guided hybrid robot system for dental implant surgery.

Purpose: Dental implant surgery is an effective method for remediating the loss of teeth. Robot is expected to increase the accuracy of dental implant surgery. However, most of them are industrial serial robot, with low stiffness and non-unique inverse kinematic solution, which may reduce the success rate and safety of robotic surgery.

[The feasibility of zygomatic implant quad approach in patients with tooth agenesis: a radiographic analysis].

Purpose: The aim of this study was to analyze the feasibility of zygomatic implant quad approach in patients with tooth agenesis.

Methods: Based on the data from cone-beam CT (CBCT), twenty one patients with tooth agenesis who were planned to receive zygomatic implant quad approach were enrolled. The radiographic bone-to-implant contact (rBIC) of each zygomatic implant placed virtually in patients' zygomatic segment was measured.

Healthcare Costs Associated with Complications in Patients with Type 2 Diabetes among 1.85 Million Adults in Beijing, China.

We aimed to provide reliable regression estimates of expenditures associated with various complications in type 2 diabetics in China. In total, 1,859,039 type 2 diabetes patients with complications were obtained from the Beijing Medical Claim Data for Employees database from 2008 to 2016. We estimated costs for complications using a generalized estimating equation model adjusted for age, sex, and the incidence of various complications.

Diffuse-type tenosynovial giant cell tumor of the temporomandibular joint with skull base invasion: a report of 22 cases with literature review.

Objectives: The aim of this study was to retrospectively analyze the clinical characteristics, surgical treatment, and prognosis of patients with diffuse-type tenosynovial giant cell tumor (D-TGCT) involving the temporomandibular joint (TMJ) and the skull base.

Study Design: A retrospective study was performed in patients with D-TGCT involving the TMJ and the skull base at our institute from April 2009 to August 2018. Data on clinical characteristics, surgical treatment, and prognosis were collected and analyzed.

[Mutation screening and functional analysis for 8 patients with ectodermal dysplasia].

Purpose: To identify the potentially pathogenic mutations in patients with ectodermal dysplasia (ED) and to investigate the pathogenicity of mutations by functional studies.

Methods: Eight Chinese ED patients were included in this study. Peripheral venous blood was taken from the patients and DNA was extracted.

Treatment of severe periodontic-endodontic combined lesions with minocycline hydrochloride ointment combined with mineral trioxide aggregate.

Periodontic-endodontic combined lesions affect the quality of life of patients. The present study aimed to explore a way to achieve maximal effect in treating periodontic-endodontic combined lesions by using a combination of minocycline hydrochloride ointment (MHO) and mineral trioxide aggregate (MTA). In the present study, 294 patients were randomly divided into four groups: Control group, MHO group, MTA group and combination group.

[Perioperative nursing of zygomatic implant surgery for patients with severe periodontitis].

Purpose: To analyze the perioperative nursing characteristics about severe periodontitis patients with immediate zygomatic implantation, and to summarize the clinical nursing experience.

Methods: Preoperatively, all patients received psychological counseling, oral hygiene instruction, and periodontal care with necessary means after physical examination. Cooperative procedures were preformed between nurses and surgeon during operation.

[Morphometric analysis of maxillofacial bone in 48 patients with ectodermal dysplasia].

Purpose: The study was performed to analyze the maxillofacial morphology of 48 patients with ectodermal dysplasia (ED) and to provide some reference for implant treatment of ED patients.

Methods: The study collected the clinical data and lateral cephalometric radiographs of 48 patients with ED treated between June 2013 and October 2016. The patients were grouped as follows: group 1, 23 patients, at least with two kinds of ectodermal disorder, besides hypodontia; group 2, 25 patients, only with one kind of ectodermal disorder, besides hypodontia.

Measurement of the zygomatic region for the optimal placement of quad zygomatic implants.

Background: The zygomatic implant is suggested to be placed in zygomatic areas with the largest thickness, but regions to obtain the largest bone-to-implant contact (BIC) were unknown.

Purpose: To identify the zygomatic regions for placing quad zygomatic implants that obtain the largest BIC.

Materials And Methods: The zygomatic thicknesses of 300 zygomata were measured at total 12 points on the superior, middle, and inferior areas on the 3-dimensional reconstruction images.

CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study.

Objective: To understand the relationships between CDH13 (T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors.

Methods: We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight (HMW) adiponectin levels.

Accuracy of a real-time surgical navigation system for the placement of quad zygomatic implants in the severe atrophic maxilla: A pilot clinical study.

Background: A real-time surgical navigation system potentially increases the accuracy when used for quad-zygomatic implant placement.

Purpose: To evaluate the accuracy of a real-time surgical navigation system when used for quad zygomatic implant placement.

Materials And Methods: Patients with severely atrophic maxillae were prospectively recruited.

[Establishment and assessment of tibial osteoradionecrosis in rats].

Purpose: To establish a rat tibial osteoradionecrosis model and assess the model by observing clinical manifestation and histopathological examinations.

Methods: The right tibia of 6 Sprague Dawley (SD) rats (weighing 200-250 g) was irradiated by a linear accelerator (single fraction 15 Gy, total dose 60 Gy) every second week for four times. Hair and cutaneous changes of the irradiated region were observed one, two, three and four weeks after irradiation, respectively.

Profile and Correlates of Health-related Quality of Life in Chinese Patients with Coronary Heart Disease.

Background: Although coronary heart disease (CHD) is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life (HRQoL) of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.

Methods: A cross-sectional study was conducted in rural communities of Fangshan District, Beijing, China.

Eye-Lid approach for four zigomatic implant placement in the severely reabsorbed maxillae: technical note.

Up to date, zygomatic implants (ZIs) have been considered a predictable treatment modality for cases of atrophic maxilla. In some severe cases with severe vertical and/or horizontal bone resorption in the anterior maxilla, the placement of standard implants in the anterior area represents a challenge. In these arduous scenarios, performance of a zygomatic "quad-approach" might be advocated.

Differences on the biological function of three Ig isotypes in zebrafish: a gene expression profile.

LPS challenge experiment was conducted to compare the different biological function of three Ig isotypes by checking the expression of Ig heavy chain in zebrafish adult and larvae. Overall, IgM and IgZ expression exceeded IgD in both the larvae and adult, and IgM expression exceeded IgZ in the larvae at later development stages and adult. Moreover, LPS challenge induced significant up-regulation of all the three Ig isotypes in adult zebrafish, and the increase range of IgM and IgZ significantly exceeded that of IgD, indicating that the former two Ig isotypes played more important immunological role in response to antigen invasion.

[Research advances in peri-implantitis relevant factors and therapy].

Peri-implantitis has been defined as an inflammatory process affecting tissues around an osseo-integrated implant in function, and resulting in the loss of supportive alveolar bone. As it was one of the main causes which led to the failure of implant treatment, its risk factors and treatment were attracting more and more attention. This review summarized the progress of clinical research on peri-implantitis risk factors and treatments.

Linkage and association between interleukin-6 gene polymorphisms and ischemic stroke: a family-based study in the northern Chinese Han population.

Background: Numerous genetic risk factors of ischemic stroke (IS) have been reported from both candidate gene and genome-wide strategies with inconsistent results. The objective of this study was to confirm the relationship between 10 previously identified single-nucleotide polymorphisms (SNPs) and IS in the Chinese population.

Methods: A family-based study was conducted in a rural area of Beijing, with a total of 227 IS families with 622 participants recruited.