Publications by authors named "Yi-Qun Sun"
Article Synopsis
- The study analyzed whether MRI-based radiomics features can effectively predict good response (GR) to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC).
- Researchers extracted radiomics features from imaging of 1,070 LARC patients and developed models to enhance prediction accuracy, incorporating both radiomic and key clinical MRI features into a combined model.
- The combined model demonstrated strong predictive capabilities for GR, leading to better disease-free survival outcomes for patients identified as high likelihood for GR, and was validated across multiple datasets with a high-quality score.
Purpose: This study aimed to develop a postoperative MRI-based fibrosis scoring system and to assess its correlation with anorectal function in locally advanced rectal cancer (LARC) cases administered neoadjuvant chemoradiotherapy (nCRT).
Methods: Pathologically confirmed LARC cases administered nCRT and radical resection were assessed retrospectively. Based on postoperative magnetic resonance imaging (MRI) findings, anastomotic fibrosis score (AFS) and perirectal fibrosis score (PFS) were determined to evaluate the extent of fibrosis.
Immune cells are indispensable defenders of the human body, clearing exogenous pathogens and toxicities or endogenous malignant and aging cells. Immune cell dysfunction can cause an inability to recognize, react, and remove these hazards, resulting in cancers, inflammatory diseases, autoimmune diseases, and infections. Immune cells regulation has shown great promise in treating disease, and immune agonists are usually used to treat cancers and infections caused by immune suppression.
View Article and Find Full Text PDFBackground: Aberrant microRNA (miRNAs) have recently been proposed as important regulators in acquiring resistance to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in diffuse large B-cell lymphoma (DLBCL). The purpose of this study was to establish the role of miR-148b in the development of CHOP resistance in DLBCL.
Methods: The expression patterns of miR-148b, HDAC6, and Ezrin were detected in CHOP-resistant clinical specimens and a DLBCL cell line.
Objective: To study the change of nucleic acid sequence and the germicidal effect of an E. coli bacteriophage with broad host range isolated from hospital sewage as well as to study the mechanism of phage host specificity and the effect of killed bacteria by phage-disinfectant to the samples from sewage water.
Methods: To extract the nucleic acid from phage f(2) and phage with broad host range using anti-serum-carbamidine hydrochloride assay.
[Experimental study of anti-infective reconstructed bone xenograft].
Zhonghua Yi Xue Za Zhi
January 2003
Objective: To develop a new type bone graft material that can be used as primary graft in contaminated even infected bone defect.
Methods: Anti-infective reconstructed bone xenograft (ARBX) was developed by combining reconstructed bone xenograft (RBX) with gentamycin and gelatin. One piece of ARBX was implanted in the muscle pouch in right thighs of 32 mice.