Publications by authors named "Yi-Pin Ren"
Article Synopsis
- The study aimed to assess how a dual agonist for GLP-1 and GIP receptors, DA-JC4, affects Parkinson’s disease symptoms and reveals underlying cellular mechanisms.
- Experiments on a rat model demonstrated that DA-JC4 improved motor skills and protected dopaminergic neurons from damage linked to mitochondrial stress, corroborated by neurotransmitter analysis.
- The neuroprotective effects were found to involve the AKT/JNK signaling pathway, suggesting that targeting this pathway could be crucial for developing treatments for Parkinson’s disease.
Background: This study is conducted to investigate the protective role of elevated microRNA-375 (miR-375) in dopaminergic neurons in Parkinson's disease through down-regulating transcription factor specificity protein 1 (SP1).
Results: The successfully modeled rats with Parkinson's disease showed aggregated neurobehavioral change, increased neuroinflammatory response and oxidative stress, and lowered dopamine content. Parkinson's disease rats treated with overexpressed miR-375 displayed improved neurobehavioral change, ameliorated neuroinflammatory response and oxidative stress, heightened dopamine content and abated neuronal apoptosis by down-regulating SP1.
Hepatic artery aneurysm rupture is a rare cause of massive hemobilia, which is potentially life-threatening, cause of upper gastrointestinal hemorrhage. Cases of mycotic hepatic artery aneurysm associated with streptococcal endocarditis have rarely been reported. In the present study, we report a case of massive hemobilia that was caused by ruptured mycotic hepatic artery aneurysm in a patient who was infected with streptococcal endocarditis 3 months previously.
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