Multiple myeloma (MM) is an incurable hematologic malignancy, with chemotherapy being the primary treatment. However, the development of drug resistance remains a major challenge. This study aimed to identify therapeutic targets associated with drug resistance in MM and assess their prognostic significance.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2023
Background: Breast cancer is the commonest global malignancy and the primary cause of carcinoma death. MCM6 is vital to carcinogenesis, but the pathogenesis of MCM6 remains unclear.
Methods: MCM6 expression in patients with breast cancer was examined through The Cancer Genome Atlas (TCGA) database, immunohistochemistry, Quantitative Real-Time PCR (qRT‒PCR) and Western blotting.
If primordial black holes (PBHs) contribute more than 10% of the dark matter (DM) density, their energy density today is of the same order as that of the baryons. Such a cosmic coincidence might hint at a mutual origin for the formation scenario of PBHs and the baryon asymmetry of the Universe. Baryogenesis can be triggered by a sharp transition of the rolling rate of inflaton from slow-roll to (nearly) ultraslow-roll phases that produce large curvature perturbations for PBH formation in single-field inflationary models.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
October 2021
Objective: To analyze the disease types, clinical manifestations, efficacy and outcome of JAK2 V617F and BCR-ABL double-mutant myeloproliferative neoplasms (MPN), and provide a reference for the diagnosis, treatment and prognosis of MPN.
Methods: The clinical characteristics, diagnosis, therapeutic efficacy and outcome of JAK2 V617F and BCR-ABL double-mutant MPN were analyzed comprehensitively by combining a clinical case diagnosed and treated in our hospital with literature cases from CNKI and PubMed databases.
Results: A total of 38 related literatures were retrieved from the two databases by searching "JAK2 V617F" and "BCR-ABL" as key words from 1990 to 2019, and 59 cases were involved.
We present the postmodification of a diamondoid 3D supramolecular organic framework (SOF) to append [Ru(BPY)] groups through the formation of a hydrazone bond. The resulting SOF works as an efficient recyclable heterogeneous catalyst for visible-light-induced reduction of aromatic azides to amines.
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