Efficacy of a Novel Adjustable Snare Technique Versus the Conventional Technique for Converting the Orobiliary Catheter to a Nasobiliary Catheter.

Background And Object: It is a challenging step to guide a nasobiliary catheter from the mouth to the nasal cavity in endoscopic nasobiliary drainage (ENBD), and new methods are always being explored to improve the procedure. We have developed a novel device which is composed of a dedicated adjustable snare and a tongue depressor-like handle, for completing oral-nasal conversion of the ENBD tube. In this study, we aim to assess the utility of our new technique in repositioning the ENBD catheter by comparing it with conventional guidewire technique.

Serum uric acid and prediabetes progression and regression: a retrospective cohort study.

Background: The impact of serum uric acid (SUA) levels on metabolic disorders, particularly concerning the development or reversal of prediabetes, is not well understood. While high uric acid is recognized for its association with metabolic disturbances, its specific influence on prediabetes progression and regression has been insufficiently explored. This study investigates how SUA levels correlate with the natural course of prediabetes, shedding light on its management.

Effect of pesticide application techniques on thrips control in the cowpea flowering stage.

Background: Thrips are among the most damaging pests to cowpeas in Hainan, China. Conventional pesticide application methods often fail to achieve satisfactory control due to the small size and concealed habitats of thrips. This study aimed to enhance the efficacy of pesticides by improving their application techniques.

Transurethral Cylindrical Water Sac Prostate Enlargement Surgery for the Treatment of Small-Volume Benign Prostatic Hyperplasia: A Retrospective Analysis.

Aim: To investigate the clinical efficacy of transurethral columnar balloon dilation of prostate (TUCBDP) in the treatment of small-volume benign prostatic hyperplasia (BPH) and provide the optimal treatment for the surgical treatment of small volume benign prostatic hyperplasia.

Methods: This retrospective study analyzed 106 patients with small-volume BPH who underwent surgical treatment at the Department of Urology, Xiangya Changde Hospital from December 2023 to January 2024. The patients were divided into two groups based on the type of surgery received: TUCBDP group (n = 53) and transurethral resection of prostate (TURP) group (n = 53), which serves as the control group.

Investigating the Factors Influencing Postoperative Dynamic Intestinal Obstruction Following Laparoscopic Colorectal Radical Surgery.

Aim: Colorectal cancer (CRC) primarily arises from a combination of genetic, environmental, and dietary factors. Compared to traditional open surgery, minimally invasive laparoscopic surgery offers several advantages in managing CRC. This study investigates the factors influencing dynamic intestinal obstruction following laparoscopic colorectal radical surgery.

Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Colorectal Cancer Peritoneal Metastasis: A Systematic Review and Meta-Analysis.

Aim: This research aimed to evaluate the long-term survival rates and relapse-free status of colorectal cancer (CRC) patients with peritoneal metastases who underwent cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). The data are expected to provide valuable insights for determining therapeutic options for these patients.

Methods: PubMed (MEDLINE), Embase, Web of Science, Cochrane, Ovid, Scopus, and ClinicalTrials.

Efficacy of Percutaneous Kyphoplasty and Percutaneous Pedicle Screw Fixation in Managing Osteoporotic Vertebral Compression Fractures in Middle-Aged and Elderly Individuals: A Comparative Study.

Aim: This study is aims to compare the clinical efficacy and safety of percutaneous kyphoplasty (PKP) and percutaneous pedicle screw fixation (PPSF) in managing osteoporotic vertebral compression fractures (OVCFs) among middle-aged and elderly individuals.

Methods: A total of 142 patients aged 55-65 years were selected retrospectively from the Department of Orthopedics of our hospital from June 2021 to June 2023 and classified into PKP (n = 68) and PPSF (n = 74) groups. General data of patients were collected, and related perioperative indicators, Visual Analog Scale (VAS) scores, Oswestry Disability Index (ODI), Activities of Daily Living (ADL) scores, changes in Cobb angle of the fractured vertebrae, vertebral compression rate, as well as postoperative complications were compared between the two groups.

Application of Osborne's Ligament Suspension and Ulnar Nerve Anterior Transposition in Conjunction with Transcutaneous Electrical Nerve Stimulation for Managing Cubital Tunnel Syndrome: A Retrospective Study.

Aim: To explore the effectiveness and safety of Osborne's ligament suspension and ulnar nerve anterior transposition (OLSUNAT) in conjunction with transcutaneous electrical nerve stimulation (TENS) for managing cubital tunnel syndrome (CTS).

Methods: A total of 116 individuals diagnosed with CTS who underwent OLSUNAT in our hospital between October 2020 and December 2023 were retrospectively selected. They were divided into a treatment group (62 cases) and a control group (54 cases) based on whether they received subsequent TENS.

Gender Differences in Dendritic Damage, Gut Microbiota Dysbiosis, and Cognitive Impairment During Aging Processes.

Background: Cognitive impairment is a common and feared characteristic of aging processes, and one key mechanism of cognition is hippocampal synaptic structure. Previous studies have reported that gut microbiota dysbiosis occurred in neurodegenerative diseases and other brain disorders with cognitive impairment. However, it is not clear how gender differences affect cognitive impairment in aging processes and whether they affect synaptic structure and gut microbiota.

CeJAZ3 suppresses longifolene accumulation in Casuarina equisetifolia, affecting the host preference of Anoplophora chinensis.

Background: Casuarina equisetifolia, a crucial species of coastal windbreaks, is highly susceptible to infestation by Anoplophora chinensis. This stem-boring pest poses a significant threat to the health and sustainability of Casuarina equisetifolia forests. Understanding the molecular mechanisms underlying the host preference of A.

Heterogeneous blood pressure treatment effects on cognitive decline in type 2 diabetes: A machine learning analysis of a randomized clinical trial.

Aim: We aimed to identify the characteristics of patients with diabetes who can derive cognitive benefits from intensive blood pressure (BP) treatment using machine learning methods.

Materials And Methods: Using data from the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) study, 1349 patients with type 2 diabetes who underwent BP treatment (intensive treatment targeting a systolic BP <120 mmHg vs. standard treatment targeting <140 mmHg) were included in the machine learning analysis.

Effects of potassium fertilization on grain yield, taste quality, and starch characteristics of rice (Oryza sativa L.) grain.

Background: There is limited information on the effect of potassium (K) on the taste quality of rice. Field experiments with five K fertilizer application rates (0, 60, 120, 180, and 240 kg KO ha) were conducted in 2019 and 2020 using two cultivars (Xiadao No. 1 and Shenliangyou 5814) to study the effects of K fertilization on grain yield, taste quality, starch components, and protein components in grains.

Graphene-Assisted Electron-Based Imaging of Individual Organic and Biological Macromolecules: Structure and Transient Dynamics.

Characterizing the structures, interactions, and dynamics of molecules in their native liquid state is a long-existing challenge in chemistry, molecular science, and biophysics with profound scientific significance. Advanced transmission electron microscopy (TEM)-based imaging techniques with the use of graphene emerged as promising tools, mainly due to their performance on spatial and temporal resolution. This review focuses on the various approaches to achieving high-resolution imaging of individual molecules and their transient interactions.

Achieving over 20% Efficiency in Laminated HTM-Free Carbon Electrode Perovskite Solar Cells through In Situ Interface Reconstruction.

Laminating a free-standing carbon electrode film onto perovskite film is a promising method for fabricating HTM (hole transport material)-free carbon electrode perovskite solar cells (c-PSCs), offering more flexibility by decoupling the processes of carbon electrode and perovskite layer formation. However, the power conversion efficiency (PCE) of laminated HTM-free c-PSCs (<16.5%) remains lower compared to c-PSCs with printed carbon pastes (>20%), primarily due to poor interfacial contact between the perovskite and carbon layers.

Dynamic gastrointestinal digestion of tilapia (Oreochromis mossambicus) skin gelatin: changes of hydrolysate properties and dipeptidyl peptidase IV inhibitory activity.

Background: It is important to study the physicochemical properties of tilapia (Oreochromis mossambicus) skin gelatin and the changes in dipeptidyl peptidase IV (DPP-IV) inhibition activity during gastrointestinal digestion in order to understand and exploit the potential of tilapia as a source of DPP-IV inhibitory peptides.

Results: The DPP-IV inhibition of fish-skin gelatin increased from 9.92 ± 0.

Research hotspots and frontiers of vagus nerve stimulation in stroke: a bibliometric analysis.

Background: Vagus nerve stimulation (VNS) has emerged as a promising therapeutic approach for stroke treatment, drawing significant attention due to its potential benefits. However, despite this growing interest, a systematic bibliometric analysis of the research landscape is yet to be conducted.

Methods: We performed a comprehensive search of the Web of Science Core Collection (WoSCC) database for literature published between January 1, 2005, and August 31, 2024.

A machine learning-based predictive model for predicting early neurological deterioration in lenticulostriate atheromatous disease-related infarction.

Background And Aim: This study aimed to develop a predictive model for early neurological deterioration (END) in branch atheromatous disease (BAD) affecting the lenticulostriate artery (LSA) territory using machine learning. Additionally, it aimed to explore the underlying mechanisms of END occurrence in this context.

Methods: We conducted a retrospective analysis of consecutive ischemic stroke patients with BAD in the LSA territory admitted to Dongyang People's Hospital from January 1, 2018, to September 30, 2023.

Involvement of the parabrachial nucleus in emergence from general anesthesia.

The parabrachial nucleus (PBN), located in the dorsolateral pons, is involved in many important biological functions, such as sensory signaling, feeding, defensive behaviors, fear, anxiety, and sleep-wake cycles. General anesthesia shares the classical feature of reversible loss of consciousness with natural sleep, and accumulating evidence has indicated that general anesthesia and sleep-wake behaviors share some common underlying neural mechanism. In recent years, emerging studies have investigated the involvement of PBN in emergence from general anesthesia, but divergence exists in terms of different types of general anesthetics or different durations of treatment with the same group of general anesthetics.

Screening and regulatory mechanism exploration of M1 macrophage polarization and efferocytosis-related biomarkers in coronary heart disease.

Background: Macrophage polarization and efferocytosis have been implicated in CHD. However, the underlying mechanisms remain elusive. This study aimed to identify CHD-associated biomarkers using transcriptomic data.

Association between positive youth development and family functioning in the Chinese context: a four-wave longitudinal survey in mainland China.

Introduction: There is a notable scarcity of research examining the developmental trajectories of positive youth development (PYD) attributes among Chinese preadolescents and adolescents and the predictive effect of family functioning on these trajectories over time.

Methods: Using four waves of data, this longitudinal study investigated preadolescents and adolescents in China in January 2020 (T1), June 2020 (T2), June 2021 (T3), and June 2022 (T4). The study utilized the 90-item "Chinese Positive Youth Development Scale" and the 33-item "Chinese Family Assessment Instrument" to assess PYD and family functioning, respectively.

Psychiatric disorders in patients with benign and malignant sinonasal tumors: a prospective cross-sectional study.

Objective: To assess the prevalence of depression, anxiety, insomnia, and somatic symptom disorder (SSD) in patients with benign and malignant sinonasal tumors.

Materials And Methods: Pretreatment patients with sinonasal tumors were prospectively recruited on the rhinology ward of a tertiary hospital from July 2021 to March 2022. The electronic questionnaire which contains the rhinological symptom scale, the 22-item Sinonasal Outcome Test (SNOT-22) Scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Insomnia Severity Index (ISI), and the Patient Health Questionnaire-15 (PHQ-15) was filled out by patients at admission.

The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability.

Glabridin, a flavonoid derived from the plant , has garnered significant attention due to its diverse pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, hypolipidemic, and hypoglycemic activities. Studies have shown that glabridin exhibits substantial antitumor activity by modulating the proliferation, apoptosis, metastasis, and invasion of cancer cells through the targeting of various signaling pathways, thus indicating its potential as a therapeutic agent for malignant tumors. To enhance its solubility, stability, and bioavailability, several drug delivery systems have been developed, including liposomes, cyclodextrin inclusion complexes, nanoparticles, and polymeric micelles.

Case report: Carcinosarcoma of uterus in nulliparous women.

Background: Uterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a cancer that include both carcinomatous and sarcomatous components, resembling endometrial carcinoma. A 55-year-old woman was admitted to the hospital with postmenopausal vaginal bleeding. Gross examination of the specimen revealed brittle tissue in the fundus and the left wall of the endometrium.