Publications by authors named "Yi-Ming Kao"
Objective: To develop a high-fidelity mathematical model intended to replicate the cardiovascular (CV) responses of a critically ill patient to vasoplegic shock-induced hypotension and vasopressor therapy.
Methods: The mathematical model consists of a lumped-parameter CV physiology model with baroreflex modulation feedback and a phenomenological dynamic dose-response model of a vasopressor. The adequacy of the proposed mathematical model was investigated using an experimental dataset acquired from 10 pigs receiving phenylephrine (PHP) therapy after vasoplegic shock induced via sodium nitroprusside (SNP).
Article Synopsis
- Urinary output (UOP) is commonly used to gauge fluid resuscitation during burns, but it's not very reliable for assessing fluid responsiveness.
- This study tested whether advanced monitoring methods, like arterial pulse wave analysis (PWA), could provide better insights into cardiac output (CO) and stroke volume (SV) during burn treatment.
- Results showed that PWA-derived indices closely matched reference CO and SV measurements and may offer valuable information alongside UOP for effective burn resuscitation.