Publications by authors named "Yi-Ming Guan"
Nirmatrelvir/ritonavir use in patients with COVID-19 on hemodialysis: a case series.
Diagn Microbiol Infect Dis
November 2023
Patients undergoing hemodialysis (HD) are particularly vulnerable to coronavirus disease 2019 (COVID-19) and are at increased risk of developing severe infection. However, given the exclusion of such patients from clinical trials, there are limited data regarding the effectiveness of the antiviral drug nirmatrelvir/ritonavir (N/R) in patients on HD. We prescribed N/R to 4 patients on HD with COVID-19 after obtaining informed consent.
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- An annual medicinal herb called L. was identified as suffering from a fungal disease in a field in China during July 2021, affecting over 32% of the plants.
- Symptoms included irregular gray spots on the leaves which expanded from older to younger ones, resulting in lesions that developed a white center and could merge.
- Ten symptomatic leaves were collected for lab analysis, leading to the isolation of fifteen fungal strains, with isolate JL6 selected for further study, showing characteristics consistent with specific fungi descriptions and confirmed through genetic sequencing.
Article Synopsis
- * A study sampled 1,000 ginseng roots from cold storage facilities, revealing an average disease incidence of 21%, characterized by soft lesions, surface detachments, and internal decay as the infection spread between roots.
- * Identification of the disease-causing agent resulted in the isolation of 22 suspected Sclerotinia isolates, with specific characteristics of fast-growing colonies and sclerotia formation confirmed after laboratory incubation.
Mitochondrial dysfunction in proximal tubular epithelial cells is a key event in acute kidney injury (AKI), which is a risk factor for the development of chronic kidney disease (CKD). Apelin is a bioactive peptide that protects against AKI by alleviating inflammation, inhibiting apoptosis, and preventing lipid oxidation, but its role in protecting against mitochondrial damage remains unknown. Herein, we examined the protective effects of apelin on mitochondria in cisplatin-stimulated human renal proximal tubular epithelial cells and evaluated its therapeutic efficacy in cisplatin-induced AKI mice.
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- American ginseng, a medicinal plant mainly grown in China, suffers from anthracnose, a serious disease that causes over 20% production loss annually.
- In July 2019, anthracnose was found on 3-year-old ginseng plants in Jilin Province, with symptoms including brown, sunken lesions on leaves that led to wilting and substantial infection rates (over 36%) in a large field.
- Researchers collected infected leaves, cultured them in a lab, and identified a specific isolate (XTJ2) that displayed unique colony characteristics and spore morphology, initially classifying it as a new species of pathogen.
Panax rusty root rot caused by the species complex is a devastating disease, and it is one of the main factors contributing to the difficulty in continual cropping. Rusty root rot occurs in all ginseng fields, but little is known about the taxonomy of the fungal pathogen complex, especially and -like species. Rusty root rot samples were collected from commercial ginseng cultivation areas of China, and the pathogens were isolated and purified as single spores.
View Article and Find Full Text PDFSiberian ginseng ( (Rupr. & Maxim.) S.
View Article and Find Full Text PDFBunge (Fabaceae) is a perennial medicinal herb widely cultivated in China. In June 2018, root rot was observed on two-year-old plants in Chaoyangshan town (northeastern China). In a 40-ha field, over 40% of the plants exhibited root rot and the infected area ranged from 10 to 70% of the roots.
View Article and Find Full Text PDFWith rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management.
View Article and Find Full Text PDFThe utility of traditional methods for detecting seed-borne fungi is limited by the fact some fungi are unculturable or difficult to isolate. The seed-borne pathogens affecting cultivation have not been fully characterized. Seed-borne fungi can be identified based on the high-throughput sequencing of internal transcribed spacer (ITS) amplicons.
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