PERK+ macrophages drive immunotherapy resistance in lymph node metastases of oral squamous cell carcinoma.

Purpose: Neoadjuvant anti-PD-1 immunotherapy combined with chemotherapy has shown promising pathological responses in various cancers, including oral squamous cell carcinoma (OSCC). However, the pathological response of lymph node (LN) metastases remains poorly understood. This study aims to systematically evaluate the pathological response rates (pRRs) of LN metastases in OSCC patients and identify potential targets to improve therapeutic outcomes.

Asymmetrical Interactions between Ni Single Atomic Sites and Ni Clusters in a 3D Porous Organic Framework for Enhanced CO Photoreduction.

3D porous organic frameworks, which possess the advantages of high surface area and abundant exposed active sites, are considered ideal platforms to accommodate single atoms (SAs) and metal nanoclusters (NCs) in high-performance catalysts; however, very little research has been conducted in this field. In the present work, a 3D porous organic framework containing Ni SAs and Ni NCs is prepared through the metal-assisted one-pot polycondensation of tetraaldehyde and hexaaminotriptycene. The single metal sites and metal clusters confined in the 3D space created a favorable micro-environment that facilitated the activation of chemically inert CO molecules, thus promoting the overall photoconversion efficiency and selectivity of CO reduction.

Single-atom tailored atomically-precise nanoclusters for enhanced electrochemical reduction of CO-to-CO activity.

The development of facile tailoring approach to adjust the intrinsic activity and stability of atomically-precise metal nanoclusters catalysts is of great interest but remians challenging. Herein, the well-defined Au nanoclusters modified by single-atom sites are rationally synthesized via a co-eletropolymerization strategy, in which uniformly dispersed metal nanocluster and single-atom co-entrenched on the poly-carbazole matrix. Systematic characterization and theoretical modeling reveal that functionalizing single-atoms enable altering the electronic structures of Au clusters, which amplifies their electrocatalytic reduction of CO to CO activity by ~18.

Electropolymerization of Metal Clusters Establishing a Versatile Platform for Enhanced Catalysis Performance.

Atomically precise metal clusters are attractive as highly efficient catalysts, but suffer from continuous efficiency deactivation in the catalytic process. Here, we report the development of an efficient strategy that enhances catalytic performance by electropolymerization (EP) of metal clusters into hybrid materials. Based on carbazole ligand protection, three polymerized metal-cluster hybrid materials, namely Poly-Cu cba, Poly-Cu Au cbz and Poly-Cu Ag cbz, were prepared.

Fabrication of silver chalcogenolate cluster hybrid membranes with enhanced structural stability and luminescence efficiency.

The present study reports the fabrication of a silver chalcogenolate cluster hybrid membrane (SCC membrane) through self-assembly of SCCs, and then covalent cross-linking of the modified SCC assembled materials. This strategy provides access to silver clusters with superior chemical stability and enhanced luminescence efficiency for practical applications.