Publications by authors named "Yi-Man Peng"
[Research Progress and New Immunotherapy Strategies of Tumor Microenvironment Metabolism].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2023
The tumor microenvironment (TME), the environment of tumorigenesis and tumor progression, incorporates multiple types of cells and non-cellular components. TME plays an important role in tumorigenesis and tumor progression. Due to the abnormal proliferation of tumors, the TME has a unique chemophysiology environment and complex metabolic patterns, which subsequently affects the role of immune cells.
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- SSRIs and SNRIs are widely used antidepressants, and this study examines their effects on astrocytes, which are brain cells linked to neuroinflammation and depression.
- The results showed that SSRIs caused cytotoxicity and altered inflammatory responses in astrocytes, while the SNRI venlafaxine was less toxic and affected inflammation differently.
- These findings reveal the complex interactions between antidepressants and astrocyte function, offering insights into their varying effects and tolerability in depression treatment.