Protective Effect and Possible Mechanisms of Astragaloside IV in Animal Models of Diabetic Nephropathy: A Preclinical Systematic Review and Meta-Analysis.

Astragaloside IV (AS-IV) has a variety of biological activities and is widely used to treat kidney diseases. We conducted a systematic review of 24 animal studies including 424 animals to evaluate the efficacy of AS-IV for diabetic nephropathy (DN); all current possible mechanisms were summarized. A search strategy was applied to eight databases from inception to June 2020.

The Prognostic Value of the Expression of mRNA in Breast Cancer.

Aim: To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 () in breast cancer.

Methods: A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed.

Results: mRNA level was significantly upregulated in breast cancer tissues ( < 0.

Effects of alliin on LPS-induced acute lung injury by activating PPARγ.

Alliin is a garlic organosulfur compound that possesses various pharmacological properties. In the present study, the protective effects and molecular mechanism of alliin on Lipopolysaccharides (LPS)-induced acute lung injury (ALI) were analyzed. LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS.