Biosynthesis of a Bioactive Meroterpene Bakuchiol in Yeast.

Bakuchiol (BAK), a specialized meroterpene, is known for its valuable biological properties and has recently gained prominence in cosmetology for its retinol-like functionality. However, low abundance in natural sources leads to environmentally unfriendly and unsustainable practices associated with crop-based manufacturing and chemical synthesis. Here, we identified a prenyltransferase (PT) from that catalyzes the reverse geranylation of a nonaromatic carbon in -coumaric acid (-CA), coupled with a decarboxylation step to form BAK.

Epicoccanes A-D, Four Oxidative Dimers of Pyrogallol Analogues from .

Epicoccanes A-D (-) are four novel metabolites of an endophytic fungus . Their distinct unprecedented structures are hypothesized as oxidative dimers of pyrogallol analogues. Compounds and possess a novel spirobicyclo[3.

Beetleane A and Epicoane A: Two Carbon Skeletons Produced by .

Two novel natural products, beetleane A () and epicoane A (), were obtained from the metabolites of an endophytic . Compound has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.

Enhancing Attention by Synchronizing Respiration and Fingertip Pressure: A Pilot Study Using Functional Near-Infrared Spectroscopy.

Sustained attention is a fundamental ability ensuring effective cognitive processing and can be enhanced by meditation practice. However, keeping a focused meditative state is challenging for novices because involuntary mind-wandering frequently occurs during their practice. Inspired by the potential of force-control tasks in invoking internal somatic attention, we proposed a haptics-assisted meditation (HAM) to help reduce mind-wandering and enhance attention.