Publications by authors named "Yi-Lee Ting"
Article Synopsis
- Before next-generation sequencing (NGS), neuropathy evaluations relied on limited genetic tests and screening for acquired causes, particularly for patients with a family history and earlier symptom onset.
- In this study of 6,849 adults, researchers used NGS to examine a wider range of genes related to peripheral neuropathy, resulting in a molecular diagnosis for 8.4% of patients.
- The findings indicate that many significant diagnoses and potential clinical interventions would have been overlooked under previous testing guidelines, underscoring the need to update genetic testing practices to include more genes and better distinguish between hereditary and acquired neuropathy.
MurAs (enolpyruvyl-UDP-GlcNAc synthases) from pathogenic bacteria such as Borrelia burgdorferi (Lyme disease) and tuberculosis are fosfomycin resistant because an Asp-for-Cys substitution prevents them from being alkylated by this epoxide antibiotic. Previous attempts to characterize naturally Asp-containing MurAs have resulted in no protein or no activity. We have expressed and characterized His-tagged Lyme disease MurA (Bb_MurA(H6)).
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