Publications by authors named "Yi-Lan Zeng"
Background And Aims: Chronic hepatitis B (CHB) can cause liver fibrosis and lead to cirrhosis and cancer. As the effectiveness of antiviral therapy to reverse liver fibrosis is limited, We aimed to evaluate the effect of An-Luo-Hua-Xian pill (ALHX) on fibrosis regression in CHB patients treated with entecavir (ETV).
Methods: Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX (ETV+ALHX) between October 1, 2013 and December 31, 2020.
Combination therapy with pegylated interferon (PEG-IFN) and nucleos(t)ide analogues (NAs) can enhance hepatitis B surface antigen (HBsAg) clearance. However, the specific treatment strategy and the patients who would benefit the most are unclear. Therefore, we assessed the HBsAg loss rate of add-on PEG-IFN and explored the factors associated with HBsAg loss in chronic hepatitis B (CHB) patients.
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- The study investigates the link between the duration of positive SARS-CoV-2 RNA (SPD) and the risk of recurrent positive COVID-19 test results among discharged patients.
- It included 411 participants from 8 Chinese hospitals, finding that longer SPD, especially over 28 days, significantly increases the risk of recurrence, with a two-fold increase compared to those with SPD under 14 days.
- The research highlights that individuals with hypertension and low monocyte counts are at an even higher risk for recurrent positives.
Acute-on-chronic liver failure (ACLF) is an acute liver decompensation that occurs within 4 weeks on the basis of chronic liver disease. At present, the treatments of ACLF include general supportive treatment, etiological treatment, prevention and treatment of complications, artificial liver treatment, and liver transplantation. Many studies suggest that stem cell therapy may become a new treatment for patients with ACLF.
View Article and Find Full Text PDF[Difference of Liver Enzymes in Different Metabolism States of Chronic Hepatitis B].
Sichuan Da Xue Xue Bao Yi Xue Ban
July 2017
Objective: To analyze the difference of liver enzymes in different metabolism state groups of chronic hepatitis B (CHB).
Methods: We use prospective cross-sectional study to analyze the difference of liver enzymes in different metabolism state groups in 110 cases of CHB, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and glutamyl transferase (GGT).
Results: Regardless of the presence or absence of fatty liver, the levels of ALP and GGT were increased along with the deterioration of glucose metabolism (<0.
Objective: This study aimed to assess risk factors for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) after immunoprophylaxis.
Methods: Risk factors for MTCT were assessed using a multivariate logistic regression model.
Patients: We enrolled 256 mother-child pairs with positive maternal hepatitis B surface antigens (HBsAg) between January 2010 and June 2013.
Objective: The critical illness of pandemic influenza A (H1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated with the deaths of critical patients.
Methods: Medical records of 26 critical patients with H1N1 infection admitted from Sept.
[Report of the first case of influenza A (H1N1) in mainland China].
Zhonghua Jie He He Hu Xi Za Zhi
July 2009
Objective: To investigate the clinical characteristics and management of the first confirmed imported case of influenza A (H1N1) infection in mainland China.
Methods: The description of the clinical manifestations, clinical management, infection preventing and controlling strategies were reviewed.
Results: The 30-years old male patient came back from U.