Publications by authors named "Yi-Kun Mou"
Article Synopsis
- Juvenile-onset ankylosing spondylitis (JAS) refers to patients whose symptoms begin before age 16, and it tends to have worse functional outcomes and early bone metabolism issues compared to adult-onset cases.
- A study measured inflammatory and bone metabolic markers (MMP-3, sRANKL, OPG) in JAS patients, finding significantly higher levels of MMP-3 and sRANKL, while OPG levels were only slightly elevated compared to healthy controls.
- The research indicated that MMP-3 levels correlated positively with disease activity (BASDAI) and function (BASFI), while sRANKL levels were linked to MMP-3 and inversely
Two new compounds, rubescensins Q and R (1 and 2), and a new acetonide derivative (3) of lasiodonin, together with thirteen known analogues, oridonin (4), ponicidin (5), wikstroemioidin B (6), lasiodonin (7), lasiokaurin (8), enmenol (9), 1-O-beta-D-glucopyranosyl-enmenol (10), trichokaurin (11), the acetonide of maoyecrystal F (12), rabdoternins A-D (13-16), have been isolated from Isodon rubescens var. taihangensis. The structures of the new compounds were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis.
View Article and Find Full Text PDFFour new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.
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