Publications by authors named "Yi-Kai Dou"
Article Synopsis
- - Adolescents with major depressive disorder (MDD) often show executive dysfunction, impacting their social functionality; this study focused on understanding the brain networks related to this cognitive issue.
- - Researchers compared 24 adolescents with MDD to 43 healthy controls using a specific task (Intra-Extra Dimensional Set Shift Task) and found that those with MDD made more errors and had a negative correlation between task performance and anxiety levels.
- - The study identified a multimodal brain network related to executive function in adolescents with MDD, showing that lower brain activity and reduced gray matter were linked to more errors on cognitive tasks, which could enhance understanding of depression-related cognitive issues.
Background: Previous neuroimaging studies have reported structural and functional brain abnormalities in major depressive disorder (MDD). This study aimed to explore whether the coherence of structural-functional networks was affected by disease and investigate its correlation with clinical manifestations.
Methods: The severity of symptoms and cognitive function of 121 MDD patients and 139 healthy controls (HC) were assessed, and imaging data, including diffusion tensor imaging, T1 structural magnetic resonance imaging (MRI) and resting-state functional MRI, were collected.