Publications by authors named "Yi-Jun Ke"
Front Pharmacol
September 2023
Article Synopsis
- Percutaneous left atrial appendage occlusion (LAAO) is used to prevent strokes in patients with nonvalvular atrial fibrillation, but there's uncertainty about the best post-procedure antithrombotic therapy.*
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- This study analyzed the safety and effectiveness of different antithrombotic strategies—dual antiplatelet therapy (DAPT), direct oral anticoagulants (DOACs), and vitamin K antagonists (VKAs)—by reviewing outcomes from 10 studies involving 1,674 patients.*
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- The findings showed no significant differences in stroke, device-related thrombus, and major bleeding across the strategies, but DAPT was the least effective, while VKAs
Front Pharmacol
March 2022
Article Synopsis
- Hypercoagulability and thromboembolic events in COVID-19 patients lead to worse outcomes, prompting investigation into chronic oral anticoagulation (OAC) and its effects on prognosis.
- A comprehensive analysis included 12 studies with 30,646 patients and revealed that chronic OAC did not significantly decrease all-cause mortality (RR: 0.92) or ICU admissions (RR: 0.65) compared to non-OAC patients.
- The study also found that there was no difference in mortality risk between patients using direct oral anticoagulants (DOACs) and those using vitamin K antagonists (VKAs).
