Publications by authors named "Yi-Jun Cheng"
Article Synopsis
- The study investigated trends in liver cancer incidence in Hong Kong, Sweden, and the United States from the 1970s to 2021, using statistical methods to analyze data.
- Hong Kong experienced a steady decrease in liver cancer rates, while Sweden and the U.S. saw increases, with the U.S. showing a recent decline since 2015 primarily in hepatocellular carcinoma cases.
- The differences in trends across these regions might stem from varying causes and the effectiveness of preventive measures implemented in each population.
Article Synopsis
- The study investigates the role of Phosphoglycerate kinase 1 (PGK1) in radioresistance, focusing on its effects in U251 glioma cells.
- Researchers used short hairpin RNA (shRNA) to inhibit PGK1 expression in these cells and examined tumor growth in response to radiotherapy.
- The findings indicate that reducing PGK1 levels enhances the sensitivity of tumors to radiation, suggesting it could be a potential target for treating radioresistant gliomas.
Phosphoglycerate kinase 1 (PGK1) has been found to be increased in radioresistant astrocytomas. The present study was designed to investigate the potential role of PGK1 in the radioresistance in U251 human cells. Quantitative PCR and western blot analysis were performed to evaluate PGK1 expression for mRNA levels and protein levels, respectively.
View Article and Find Full Text PDFThe purpose of this study is to evaluate the steaming-induced chemical transformation of red ginseng manufactured from fresh ginseng by means of simultaneous quantitative and qualitative analyses with a combinative high-performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-ESI-MS/MS(n)) technique. Thirty-six ginsenosides were identified in red ginseng and white ginseng by comparing the mass spectrum and/or matching the empirical molecular formula with that of known published compounds, and 11 of them were determined to be newly generated during the red ginseng preparatory process. The mechanisms involved were further deduced to be hydrolysis, dehydration, isomerization, and decarboxylation at C-20, and hydrolysis also occurs at C-3 or C-6 of the original ginsenosides through the mimic process of steaming and heating in laboratory.
View Article and Find Full Text PDFBackground: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.
Method: In this study, we present a "system to system" (S2S) mode.