Publications by authors named "Yi-Jie Shi"
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is challenging. In this study, we identified artemisinins as anti-PCOS agents.
View Article and Find Full Text PDFObjective: Brown adipose tissue (BAT) development and function are essential for maintaining energy balance. However, the key factors that specifically regulate brown adipogenesis require further identification. Here, we demonstrated that the nuclear receptor subfamily 2 group F member 6 (NR2F6) played a pivotal role in brown adipogenesis and energy homeostasis.
View Article and Find Full Text PDFArticle Synopsis
- Researchers have identified CLCF1 as a negative regulator of brown fat thermogenesis, which is problematic as it contributes to obesity by reducing energy expenditure and cold tolerance.* -
- In response to obesity, CLCF1 levels increase, leading to the suppression of mitochondrial function in brown adipocytes and causing them to "whiten," or lose their thermogenic capability.* -
- Blocking the pathways involving CLCF1 and its signaling partners may help restore brown fat function and improve metabolic health in individuals struggling with obesity.*
[CT manifestation of environmental asbestos pollution induced pleural plaques].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
May 2008