Publications by authors named "Yi-Jia Shen"
MiR-30d Participates in Vincristine-Induced Neuropathic Pain by Down-Regulating GAD67.
Neurochem Res
February 2022
Article Synopsis
- Vincristine, a common chemotherapy drug, can cause chemotherapy-induced peripheral neuropathy (CIPN), leading to significant pain and economic burden for patients.
- The study found that GAD67, an enzyme critical for GABA synthesis (an inhibitory neurotransmitter), is down-regulated in vincristine-induced neuropathy, while its mRNA levels remain unchanged.
- Researchers identified miR-30d as a microRNA that may be responsible for this down-regulation, and blocking miR-30d improved GAD67 levels and reduced pain symptoms in affected models, providing new insights into the mechanisms behind CIPN and potential pain management strategies.
Article Synopsis
- Paclitaxel, a common chemotherapy drug, can lead to chemotherapy-induced peripheral neuropathy (CIPN), causing pain symptoms like hyperalgesia and allodynia, but the underlying mechanisms are not well understood.
- Research highlights that matrix metalloproteinase-2 (MMP-2) is upregulated in paclitaxel-induced neuropathic pain and that reducing MMP-2 through siRNA can lessen pain sensitivity.
- The study finds that the upregulation of MMP-2 is linked to decreased DNA methylation of its promoter, influenced by the SUMOylation of the DNA methyltransferase DNMT3b, suggesting that targeting these molecular pathways may provide new treatment strategies for