Publications by authors named "Yi-Jia Ma"
Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research.
Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group.
Background: Docetaxel (DTX) exhibits antitumor effects against breast cancer by stabilizing microtubules and increasing the accumulation of reactive oxygen species (ROS). DTX extravasation during infusion often causes skin injury. The present study aimed to investigate the effects and mechanisms of icaritin (ICT) on DTX-induced skin injury.
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- - Nutraceuticals that activate the Keap1-Nrf2-ARE pathway are explored for treating nonalcoholic fatty liver disease (NAFLD) since there are no specific approved drugs yet
- - NAFLD progression is based on the 'two-hit' hypothesis: the first hit involves insulin resistance and lipid accumulation, while the second hit involves oxidative stress and inflammation
- - The Keap1-Nrf2-ARE pathway has a complex role in NAFLD; it can either help reduce insulin resistance during the first hit or combat oxidative stress and inflammation during the second hit, leading to discussions about using its inhibitors for early treatment