Publications by authors named "Yi-Jia Fang"
Executive dysfunction is common in Parkinson's disease (PD) patients. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to affect executive functions (EFs) in the prefrontal cortex. The present study attempted to explore the influence of the COMT polymorphism on EFs in patients with PD.
View Article and Find Full Text PDF[Differential Regulation of Bruton's Tyrosine Kinase by the Ubiquitin Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2017
Article Synopsis
- The study aimed to understand how Bruton's tyrosine kinase (Btk) is regulated and its underlying mechanisms.
- Researchers used various treatments to assess the mRNA and protein levels of Btk and found that its expression is influenced by factors like proteasome inhibitors and phorbol esters (PMA).
- The results indicate that Btk is regulated through ubiquitination, particularly by the E3 ligase Cbl, impacting its stability and activation in cells.
[Establishment of Human Acute B-Lymphoblastic Leukemia--NOD/SCID Xenotransplant Mouse Model].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2015
Objective: To establish human B-acute lymphoblastic leukemia NOD/SCID mouse model.
Methods: The unirradiated mice aged 4-5 weeks were injected with Nalm-6 cells via the tail vein. Successful transplantation was assessed by the general state, bone marrow smear and histopathologic examination.