Design, synthesis, and antimicrobial activities of novel functional peptides against Gram-positive and Gram-negative bacteria.

The extensive use of antibiotics in medicine results in the multidrug resistance of bacteria, making the development of new antimicrobial agents an urgent need. Antimicrobial peptides (AMPs) are considered as a new class of antibiotic with characteristics including an ability to kill target cells rapidly and a broad spectrum of activity. We have developed a potent antimicrobial peptide MAP-0403 (MIC = 5 μM), but it exhibited a high hemolytic side-effect (70.