Aim: To evaluate the effects of etanercept on the expression of Fas, tumor necrosis factor-alpha (TNF-α) and caspase-8 in the early stage of the apoptotic pathway in diabetic rats, and to explore the therapeutic effect of etanercept on diabetic retinopathy.
Methods: A total of 60 Sprague-Dawley (SD) rats were randomly and evenly divided into 3 groups with 20 rats each, including control group, and diabetic groups with or without treatment. Streptozotocin (STZ)-induced diabetic rats were established for diabetic groups.
Aim: To identify the mutations of , , and in a large Chinese family affected by juvenile open angle glaucoma (JOAG).
Methods: Of 114 members of one family were recruited in this study. Blood samples from twelve members of this pedigree were collected for further research.