Publications by authors named "Yi-Hao Hsu"
Eur J Pharmacol
March 2024
Article Synopsis
- * Natural compounds Pterostilbene (PTE) and 6-shogaol (6-S) have shown promise in enhancing the effectiveness of SUN in treating resistant RCC cells by triggering cell death and reducing drug resistance.
- * The study found that PTE and 6-S could disrupt specific cell signaling pathways and reduce cell invasiveness, suggesting they could be beneficial as adjunct therapies alongside SUN in RCC treatment.
Article Synopsis
- Dysbiosis of gut microbiota is linked to ulcerative colitis and the metabolism of dietary fiber boosts anti-inflammatory short-chain fatty acids (SCFAs) production.
- The study explored the effects of Aspergillus oryzae-fermented okara on preventing colitis in a rat model, showing it increased SCFAs-producing bacteria and reduced inflammation markers.
- Results indicate that fermented okara enhances antioxidant activity and reduces intestinal inflammation, suggesting its potential as a functional food to improve gut health.
Article Synopsis
- * Lucidone, a natural compound from Lindera erythrocarpa, shows promise in enhancing the effectiveness of chemotherapy by inducing cell death and reducing autophagy and MDR1 expression through targeting the HMGB1/RAGE/PI3K/Akt pathway.
- * The study finds that combining lucidone with gemcitabine improves treatment outcomes in PDAC cell lines, suggesting a potential strategy for overcoming drug resistance.
Phytomedicine
January 2021
Article Synopsis
- Researchers explored the gastroprotective effects of Trichodesma khasianum (T. khasianum) leaves, aiming to find a safe alternative for treating peptic ulcers due to side effects from traditional drugs.
- The study methods involved testing T. khasianum leaves on gastric injury and gut health using various lab techniques and animal models, showing promising results.
- The results indicated that the leaf extract effectively promoted gastric healing, reduced inflammation, and improved gut microbiota diversity without causing toxicity, marking a significant step in understanding its protective effects.*
Article Synopsis
- * Pterostilbene (PTE), a natural compound found in grapes and blueberries, shows potential in enhancing the effectiveness of chemotherapy by inducing cancer cell death and suppressing drug resistance mechanisms.
- * The study found that PTE inhibits multidrug resistance protein (MDR1) expression and promotes chemosensitivity in pancreatic cancer cells through the RAGE/PI3K/Akt signaling pathway, suggesting its role in improving cancer treatment outcomes.
