Publications by authors named "Yi-Han Jiang"
Article Synopsis
- Anxiety is an emotional response marked by worry and tension, potentially linked to the downregulation of TNRC6A in the brain's prefrontal cortex (PFC) following stress.
- Inhibition of TNRC6A increases anxious behaviors in mice, as it maintains the stability of miR-21-3p, a microRNA that can mitigate anxiety when present in higher levels.
- The study highlights a new molecular mechanism, showing that low TNRC6A levels reduce miR-21-3p stability, leading to increased corticotropin-releasing factor (CRF) levels and consequently, heightened anxiety-like behaviors.
The mechanism of action of low-density lipoprotein receptor related protein 4 (LRP4) is mediated largely via the Agrin-LRP4-MuSK signalling pathway in the nervous system. LRP4 contributes to the development of synapses in the peripheral nervous system (PNS). It interacts with signalling molecules such as the amyloid beta-protein precursor (APP) and the wingless type protein (Wnt).
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- This study investigates the link between periodontitis and Parkinson's disease (PD), showing that periodontitis worsens motor dysfunction and neuron loss in PD models.* -
- Researchers found that specific bacteria, Veillonella parvula and Streptococcus mutans, increased in the gut and were crucial for the negative impact of periodontitis on PD symptoms.* -
- The study highlights immune response changes in the brain and body due to these bacteria, suggesting that targeting these factors might help protect against neuron damage in PD.*
The quality of optode arrangement is crucial for group imaging studies when using functional near-infrared spectroscopy (fNIRS). Previous studies have demonstrated the promising effectiveness of using transcranial brain atlases (TBAs), in a manual and intuition-based way, to guide optode arrangement when individual structural MRI data are unavailable. However, the theoretical basis of using TBA to optimize optode arrangement remains unclear, which leads to manual and subjective application.
View Article and Find Full Text PDFThe mirror neuron system (MNS), mainly including the premotor cortex (PMC), inferior frontal gyrus (IFG), superior parietal lobule (SPL), and rostral inferior parietal lobule (IPL), has attracted extensive attention as a possible neural mechanism of social interaction. Owing to high ecological validity, functional near-infrared spectroscopy (fNIRS) has become an ideal approach for exploring the MNS. Unfortunately, for the feasibility of fNIRS to detect the MNS, none of the four dominant regions were found in previous studies, implying a very limited capacity of fNIRS to investigate the MNS.
View Article and Find Full Text PDFObjective: Functional near infra-red spectroscopy (fNIRS) is a promising brain imaging technology for brain-computer interfaces (BCI). Future clinical uses of fNIRS will likely require operation over long time spans, during which neural activation patterns may change. However, current decoders for fNIRS signals are not designed to handle changing activation patterns.
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