Publications by authors named "Yi-Han Gan"

Article Synopsis
  • Alzheimer's disease (AD) has complex genetics largely studied in European populations, but this study involved a GWAS with 6,878 Chinese and 63,926 European individuals to explore new genetic links to AD.
  • The research identified three new susceptibility loci (KIAA2013, SLC52A3, and TCN2) in Chinese participants and highlighted a unique variant (rs1815157) within EGFR.
  • The findings suggest that including diverse populations is key for understanding AD's genetic basis and show that high mean corpuscular hemoglobin concentration could offer some protection against the disease.
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Background: Shift work is associated with susceptibility to several neuropsychiatric disorders. This study aims to investigate the effect of shift work on the incidence of neuropsychiatric disorders, and highlighting how individual variability may influence the association.

Methods: UK Biobank participants with employment information were included.

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Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past decades, a link between the 2 disease entities has received extensive acknowledgment, yet the complex nature of this relationship demands further clarification. Some evidence indicates that midlife depression may be an AD risk factor, while a chronic course of depression in late life may be a precursor to or symptom of dementia.

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Background: This study aimed to analyze the impact of a wide spectrum of occupational characteristics on the incidence of anxiety and depression, and to determine the features affecting adaptation to specific characteristics.

Methods: Participants in paid employment or self-employed at baseline in UKB were included, with occupational characteristics extracted from O*NET. Cox-proportional-hazard models were conducted in the main analyses and subgroup analyses.

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Background: Since the epidemic continues, there is a pressing need to improve our understanding of coronavirus disease 2019 (COVID-19). Mendelian randomization (MR) studies provide us with a method to explore the causality between circulating proteins and COVID-19 susceptibility and severity. We aim to find new perspectives on the pathological mechanism of the disease and possible drug targets for treatment based on this study.

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